Submitted: 22 Oct 2022
Accepted: 22 Dec 2022
ePublished: 24 Dec 2022
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Immunopathol Persa. 2023;9(1): e38455.
doi: 10.34172/ipp.2022.38455

Scopus ID: 85145922680
  Abstract View: 868
  PDF Download: 1414


Medical plants for lung cancer: an overview of current knowledge

Mohammadreza Khosravifarsani 1 ORCID logo, Ramin Tolouian 2, Sepideh Yadollahifarsani 3, Parisa Soleimani 4, Marni Sarazen 5, Pouria Mostafizi 6, Audrey Tolouian 7* ORCID logo, Anil K. Philip 8, Zahra Golestani Hotkani 9

1 Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Southern Arizona VA Health Care System and College of Medicine, University of Arizona, Tucson, AZ, USA
3 Independent Researcher, Isfahan, Iran
4 Nickan Research Institute, Isfahan, Iran
5 Department of Internal Medicine, College of Medicine, University of Arizona, Tucson, Arizona, USA
6 Department of Physiology, College of Medicine, University of Arizona, Tucson, AZ, USA
7 Holistic Nursing Program, Northern New Mexico College, Espanola, New Mexico, USA
8 School of Pharmacy, College of Pharmacy and Nursing, University of Nizwa, Nizwa, Sultanate of Oman
9 Department of Bioscience, University of Milan, Milan, Italy
*Corresponding Author: Correspondence to Audrey Tolouian, Email: , Email: audrey.tolouian@nnmc.edu


Lung cancer is an uncontrolled cell growth in lung tissue, with changes in the cellular, epigenetic and genetic alterations, oncogenes activation and clonal evolution of malignant cells. The most critical risk factor for lung cancer is cigarette smoking (80-85%). Other reasons for lung cancer (15-20%) include genetic factors, exposure to secondhand smoke, air pollution, radiation, hazardous gases and foreign chemical agents. The most widely used strategies in lung cancer treatment are chemotherapy, radiotherapy and surgery. However, there are various adverse effects, such as significant toxicity, limited efficiency and multidrug resistance. Plants and plant-derived products have proven to have a role in lung cancer therapy and prevention through sensitizing conventional factors, extending patient survival time, avoiding adverse effects of chemotherapy, promoting physiological improvement and ameliorating quality of life in pulmonary malignancy cases. For this review article, we searched Web of Science, EBSCO, Scopus, PubMed/Medline, DOAJ (Directory of Open Access Journals), Embase, and Google Scholar, using various keywords. There are several natural product molecules with anticancer properties through many molecular mechanisms, including, inducing apoptosis, inhibition of angiogenesis and metastasis, reversion of multidrug resistance and also targeting reactive oxygen species signaling. Some phytochemical compounds are discussed as anticancer agents for lung cancer.

Citation: Khosravifarsani M, Tolouian R, Yadollahifarsani S, Soleimani P, Sarazen M, Mostafizi P, Tolouian A, Philip AK, Golestani Hotkani Z. Medical plants for lung cancer: an overview of current knowledge. Immunopathol Persa. 2023;9(1):e38455. DOI:10.34172/ ipp.2022.38455.
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