Mohammad-Reza Mahmoudian-Sani
1,2, Ameneh Mehri-Ghahfarrokhi
2, Ali Shojaeian
2, Majid Asadi-Samani
3*, Tahra Luther
41 Department of Genetics and Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2 Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
4 Department of General Surgery, University of Michigan, Ann Arbor, Michigan, USA
Abstract
MicroRNAs consist of 18 to 25 non-coding ribonucleic acids (RNA) that can act as oncogenes or tumor suppressors and in which mutations can lead to cancer. The identification of microRNAs and their target molecules has created a new horizon for studies of causes of cancer. MicroRNAs can be used as potential biological markers in diagnosis, prediction and treatment of cancers. This review article presents findings to explain microRNA’s function in human cancers.