Nickan Research Institute Immunopathologia Persa 2423-8015 7 1 2021 01 01 Isolated colon metastasis of vaginal cuff squamous cell carcinoma; a case report e01 e01 10.34172/ipp.2021.01 EN Azar Ahmadzadeh https://orcid.org/0000-0001-8931-8100 Shaghayegh Sherafatmand Mina Mohtadi Mohammad Momen Gharibvand https://orcid.org/0000-0002-1877-8019 Mohammad Bahadoram Journal Article 10.34172/ipp.2021.01 2019 06 13 2019 08 30 Primary vaginal squamous cell carcinoma (SCC) is one of the rarest kinds of cancer in gynecological cancer. We report a 40-year-old presented with abdominal pain in her right lower quadrant with past-medical history of vaginal cuff SCC without any metastasis about 2.5 years ago which was treated with a combination of surgery and radiotherapy. Ultrasonography and abdomino–pelvic CT scan suggested an inflammatory phlegmon in RLQ probably due to a complicated appendicitis or malignancy. Ultrasonography-guided biopsy was performed which showed a poor differentiated SCC. Chest and abdominopelvic CTs showed no metastasis. Patients underwent laparotomy and ileocecal resection then end-to-end anastomosis was performed. A study of specimens showed a non-keratinizing SCC.