Nickan Research Institute Immunopathologia Persa 2423-8015 11 1 2025 01 01 Evaluation of the relationship between preeclampsia and positive rectovaginal culture of group B Streptococcus and Helicobacter pylori positive serology e21 e21 10.34172/ipp.2022.21 EN Samaneh Saghafian Larijani https://orcid.org/0000-0001-5530-8203 Maryam Biglari Abhari https://orcid.org/0000-0002-9009-0593 Hosna Mirfakhraee https://orcid.org/0000-0003-1889-6389 Maryam Niksolat https://orcid.org/0000-0002-3725-7462 Danesh Aminpanah Journal Article 10.34172/ipp.2022.21 2021 08 14 2021 10 01 Introduction: Identifying the incidence of pathogen colonizations in pregnant women with preeclampsia can be effective in providing proper treatment and reducing complications. Objectives: We evaluated the frequency and association between positive rectovaginal culture of group B Streptococcus (GBS) and positive Helicobacter pylori serology with preeclampsia in two groups of pregnant women (with and without preeclampsia). Patients and Methods: The present case-control study included pregnant women with preeclampsia and healthy pregnant controls during 2019-2020. Blood and rectovaginal samples were obtained and the data were statistically analyzed using SPSS software. Results: Fifty-four people were included in the study. The mean gestational age was 36 ± 3.4 months in the preeclampsia group and 37 ± 2.9 months in the control group. There was no significant relationship between preeclampsia and H. pylori-positive serology (P=0.84). Additionally, the association between positive H. pylori serology and the severity of preeclampsia was not significant (P=0.15). However, there was a significant relationship between positive H. pylori tests with early- and late-onset preeclampsia (P=0.04). However, there was no statistically significant relationship between the positive rectovaginal culture of GBS and preeclampsia, the severity of preeclampsia, the onset time, or the weight of newborns. Conclusion: There was a significant relationship between H. pylori infection and late-onset preeclampsia in preeclamptic mothers. H. pylori screening and eradication therapy before pregnancy can prevent preeclampsia and its serious consequences in both the mother and the fetus.