Nickan Research Institute Immunopathologia Persa 2423-8015 7 2 2021 07 01 Gut microbiota in COVID-19 treatment e30 e30 10.34172/ipp.2021.30 EN Tella Sadighpour https://orcid.org/0000-0002-3131-3339 Audrey Tolouian https://orcid.org/0000-0002-9764-8510 Journal Article 10.34172/ipp.2021.30 2021 04 07 2021 05 14 A novel coronavirus (severe acute respiratory syndrome coronavirus [SARS-CoV-2]), has been causing a COVID-19 pandemic of acute respiratory syndrome in humans since December 2019. It appears to be similar in structure to the virus that caused the SARS-CoV outbreak of 18 years ago. However, in addition to the respiratory disorders, the COVID-19 patients might suffer extra-pulmonary disorders, including gut dysfunction or liver dysfunction complications, which show as gut–lung crosstalk. Fecal specimens should be considered as a source of detection of SARS-CoV-2 as one of the routine diagnostic tests in order to guide hospital’s liberation and release of quarantine of patients.