Nickan Research Institute Immunopathologia Persa 2423-8015 9 2 2023 06 17 Potential factors related to post-COVID-19 persistent symptoms; Khorshid COVID cohort study 22223 22223 10.34172/ipp.2022.22223 EN Ramin Sami https://orcid.org/0000-0002-7521-4631 Zahra Khani Khoozani https://orcid.org/0000-0001-8334-6127 Marjan Mansourian https://orcid.org/0000-0002-7217-0282 Zohre Naderi https://orcid.org/0000-0002-0554-6067 Mehdi Karami https://orcid.org/0000-0001-5829-1320 Mina Nickpour https://orcid.org/0000-0002-9628-4241 Arash Toghyani https://orcid.org/0000-0003-2342-7982 Ali Gharavinia https://orcid.org/0000-0002-8186-5158 Nastaran Sadat Hosseini https://orcid.org/0000-0001-7705-7783 Mehrnegar Dehghan https://orcid.org/0000-0002-6313-575X Midia Babahajiani https://orcid.org/0000-0002-9308-1879 Nafiseh Shokri-Mashhadi https://orcid.org/0000-0003-4967-4412 Journal Article 10.34172/ipp.2022.22223 2021 01 01 2021 02 09 Introduction: Recently, a high percentage of post-discharge patients have reported persistent symptoms after COVID-19 recovery. However, there is limited comprehensive information regarding nature’s symptoms and association with potential factors. Objectives: We aimed to assess the inpatients’ characteristics and the prevalence of COVID-19 symptoms at admission and four weeks after recovery to recognize the potential factors related to the persistent symptoms. Patients and Methods: We assessed the medical information of 262 severe and 546 non-severe COVID-19 inpatients at admission, and during the first and four weeks after post-discharge from the Khorshid COVID Cohort (KCC) study. Results: Cough, dyspnea, and fatigue were the most reported symptoms at admission, and continuously were declined over the time (all P<0.01). However, the complaint of weight loss was increased during follow-up (P=0.01). Older age (P<0.0001), male gender (P=0.02), administration of hydroxychloroquine (P=0.017), and the interval time from illness onset to visit hospital (P<0.0001) augmented the remaining respiratory symptoms risk. Additionally, more length of hospital stay correlated to the lower risk of persistent constitutional symptoms (P<0.05). Conclusion: This study points out the greater rehabilitation needs and management of persistent symptoms, in particular cough, dyspnea, fatigue and weight loss, and their related factors.