Nickan Research Institute Immunopathologia Persa 2423-8015 10 1 2024 01 01 Epididymo-orchitis in an 18-day-old boy; a rare case report e18222 e18222 10.34172/ipp.2022.18222 EN Shahrokh Mehrpisheh https://orcid.org/0000-0003-3484-3228 Vajihe Ghaffari Saravi https://orcid.org/0000-0001-9613-4043 Hanieh Noori Azadeh Memarian https://orcid.org/0000-0002-6872-1870 Journal Article 10.34172/ipp.2022.18222 2020 10 02 2020 11 19 Epididymo-orchitis is almost an acute inflammatory disease involving the epididymis and testis. Epididymo-orchitis is considered as a rare disease in childhood. We reported an 18-day-old boy with epididymo-orchitis who responded to antibiotic treatment and surgery and finally the patient was discharged in good general condition. It is a rare phenomenon in neonate that should be considered by practitioners. According to our case report, infants of any age are at risk for epididymo-orchitis, and it should always be one of the differential diagnoses in any testicular inflammation, pain, and redness. Early initiation of antibiotics and in some cases surgery can be very helpful in treating this disease.