Logo-ipp
Submitted: 28 Oct 2020
Accepted: 02 Feb 2021
ePublished: 08 Mar 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

  Abstract View: 574

Original

Predicting positive anti-thyroid peroxidase antibody chance in vitamin D deficient patients

Mahboubeh Darban 1 ORCID logo, Soraya Doust Mohamadian 1* ORCID logo, Sepideh Mahmoodifar 1 ORCID logo, Raheb Ghorbani 2 ORCID logo

1 Department of Internal Medicine, Semnan University of Medical Sciences, Semnan, Iran
2 Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran
*Correspondence to Soraya Doust Mohamadian, Email: sorayadoust@yahoo. com, dr.doustmohammadin@ semums.ac.ir

Abstract

Introduction: The relationship between vitamin D deficiency and thyroid gland disorders is controversial.

Objectives: Given the prevalence of vitamin D deficiency and the significance of thyroid disorders, the purpose of the study was to examine the relationship between anti-thyroid peroxidase (anti-TPO) antibody and vitamin D deficiency.

Patients and Methods: This cross-sectional study was conducted on 35 patients with vitamin D deficiency and 35 people as a control group with normal vitamin D considered more than 20 ng/mL. Serum TSH and anti-TPO antibody tests were assessed for all subjects in both groups. The level of 25 [OH] D3 less than 20 ng/mL was considered as the deficiency of vitamin D and the serum level of anti-TPO antibody more than 40 IU/mL as positive level.

Results: Mean age of patients with vitamin D deficiency was 37.00 ± 13.8 years and 46.3 ± 15.9 years in the control group. Mean age in the two groups was different (P=0.010). Around 51.4% of patients had vitamin D deficiency. There were no significant differences in TSH level among the groups (P=0.436). Anti-TPO antibody (anti-TPO Ab) level in 31.4% of the patients with vitamin D deficiency and in 11.4% of patients in the control group was positive with a significant difference (P=0.041). Logistic regression analysis showed the chance of positive anti-TPO Ab in people with vitamin D deficiency was 3.55% of the subjects without vitamin D deficiency (OR = 3.55, 95%, CI: 1.01-12.55, P=0.049).

Conclusion: Considering the greater chance (three-fold) of positive anti-TPO Ab titers in patients with vitamin D deficiency in this study, more interventional studies are suggested concerning the effect of vitamin D deficiency on anti-TPO Ab.


Keywords: Thyroid-stimulating hormones, Anti-thyroid peroxidase antibody, Vitamin D deficiency
Citation: Darban M, Doust Mohamadian S, Mahmoodifar S, Ghorbani R. Predicting positive anti-thyroid peroxidase antibody chance in vitamin D deficient patients. Immunopathol Persa. 2022;8(x):e0x. DOI:10.34172/ipp.2022. xx.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 575

Your browser does not support the canvas element.


PDF Download: 0

Your browser does not support the canvas element.