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Submitted: 01 Apr 2021
Accepted: 19 Jul 2021
ePublished: 13 Aug 2021
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  Abstract View: 297

Original

Correlation of systemic lupus erythematosus disease activity (SLEDAI) with serum level of albumin in lupus patients

Abbas Ali Zeraati 1 ORCID logo, Zhaleh Shariati 2 ORCID logo, Maryam Masinaee 3, Anoush Azarfar 1 ORCID logo, Katayoon Samadi 1* ORCID logo, Elmira Moradi 1 ORCID logo, Tina Zeraati 1 ORCID logo, Dorsa Zeraati 1 ORCID logo

1 Kidney Transplantation Complications Research Center, Department of Internal Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
2 Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
*Correspondence to Katayoon Samadi, Email: samadik@mums.ac.ir

Abstract

Introduction: Systemic lupus erythematosus (SLE) is a common type of rheumatologic disease. Currently there is no universally accepted “gold standard” to measure disease activity. An inexpensive and clinically reliable serological marker for disease activity would therefore be useful to guide treatment and gauge responses to treatment; however, such a marker remains elusive.

Objectives: The aim of this study is to investigate the correlation of systemic lupus erythematosus disease activity index (SLEDAI) with serum level of albumin in lupus patients.

Patients and Methods: The SLEDAI criteria were obtained by reviewing clinical records and Serum albumin, dsDNA, C3 and C4 were measured in lupus patients, and also demographic data including the patients’ age, and duration of disease were also collected.

Results: In this study, 60 patients (54 females and 6 males) age 31.10 ±6.63 years were enrolled. A significant negative correlation was observed between serum albumin and SLEDAI (P=0.001, r=-0.42), however, no significant correlation was found between serum albumin with anti-dsDNA (P=0.73, r=0.04), C3 (P=0.33, r=0.14) and C4 (P=0.74, r=-0.05). There was also a direct significant relationship between SLEDAI with anti-dsDNA (P=0.02, r= 0.31) and inverse correlations with C3 (P=0.007, r=-0.40) and C4 level (P=0.02, r=-0.31). Multiple linear regression analysis revealed that serum albumin is the most important factor in predicting SLEDAI among other factors including anti-dsDNA, C3 and C4 (β=0.64, P=0.001). SLEDAI was higher in systemic lupus erythematosus (SLE) patients with hypoalbuminemia compared to SLE patients without hypoalbuminemia (P=0.003).

Conclusion: We found a significant negative relationship between serum albumin and SLEDAI, and also the fact that SLEDAI was significantly higher in SLE patients with hypoalbuminemia than in those without hypoalbuminemia.

Keywords: Systemic lupus erythematosus, Albumin, Systemic lupus erythematosus disease activity inde
Citation: Zeraati AA, Shariati Z, Masinaee M, Azarfar A, Samadi K, Moradi E, Zeraati T, Zeraati D. Correlation of systemic lupus erythematosus disease activity (SLEDAI) with serum level of albumin in lupus patients. Immunopathol Persa. 2022;x(x):e24255. DOI:10.34172/ ipp.2022.24255.
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