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Immunopathol Persa. 2023;9(2): 22223.
doi: 10.34172/ipp.2022.22223

Scopus ID: 85164611766
  Abstract View: 1104
  PDF Download: 414

Original

Potential factors related to post-COVID-19 persistent symptoms; Khorshid COVID cohort study

Ramin Sami 1 ORCID logo, Zahra Khani Khoozani 2 ORCID logo, Marjan Mansourian 3 ORCID logo, Zohre Naderi 2 ORCID logo, Mehdi Karami 4 ORCID logo, Mina Nickpour 1 ORCID logo, Arash Toghyani 2 ORCID logo, Ali Gharavinia 5 ORCID logo, Nastaran Sadat Hosseini 2 ORCID logo, Mehrnegar Dehghan 2 ORCID logo, Midia Babahajiani 6 ORCID logo, Nafiseh Shokri-Mashhadi 7* ORCID logo

1 Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3 Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran
5 Department of Family and Emergency Medicine, School of Medicine, Azad University of Medical Science, Isfahan, Iran
6 Student Research Committee, Vice Chancellor for Research and Technology, Kurdistan University of Medical Sciences, Sanandaj, Iran
7 Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: Nafiseh Shokri-Mashhadi, Email: n.shokri@nutr.mui.ac.ir, , Email: nafiseh.shokri@yahoo.com

Abstract

Introduction: Recently, a high percentage of post-discharge patients have reported persistent symptoms after COVID-19 recovery. However, there is limited comprehensive information regarding nature’s symptoms and association with potential factors.

Objectives: We aimed to assess the inpatients’ characteristics and the prevalence of COVID-19 symptoms at admission and four weeks after recovery to recognize the potential factors related to the persistent symptoms.

Patients and Methods: We assessed the medical information of 262 severe and 546 non-severe COVID-19 inpatients at admission, and during the first and four weeks after post-discharge from the Khorshid COVID Cohort (KCC) study.

Results: Cough, dyspnea, and fatigue were the most reported symptoms at admission, and continuously were declined over the time (all P<0.01). However, the complaint of weight loss was increased during follow-up (P=0.01). Older age (P<0.0001), male gender (P=0.02), administration of hydroxychloroquine (P=0.017), and the interval time from illness onset to visit hospital (P<0.0001) augmented the remaining respiratory symptoms risk. Additionally, more length of hospital stay correlated to the lower risk of persistent constitutional symptoms (P<0.05).

Conclusion: This study points out the greater rehabilitation needs and management of persistent symptoms, in particular cough, dyspnea, fatigue and weight loss, and their related factors.



Citation: Sami R, Khani khoozani Z, Mansourian M, Naderi Z, Karami M, Nickpour M, Toghyani A, Gharavinia A, Hosseini NS, Dehghan M, Babahajiani M, ShokriMashhadi N. Potential factors related to post-COVID-19 persistent symptoms; KhorshidCOVID cohort study. Immunopathol Persa. 2023;9(2):e22223x. DOI:10.34172/ ipp.2022.22223.
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