Submitted: 18 Oct 2017
Accepted: 09 Dec 2017
ePublished: 02 Jan 2018
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Immunopathol Persa. 2018;4(1): e12-.
doi: 10.15171/ipp.2018.12
  Abstract View: 2583
  PDF Download: 1617


Histological and immunohistochemically profiles of renal cell carcinoma in northern Nigeria 

Atanda T. Akinfenwa 1,2*, Atanda O. Jareenat 1,2, David T. Noah 2

1 Department of Pathology, Bayero University, Kano, Nigeria
2 Department of Pathology, Aminu Kano Teaching Hospital, Kano, Nigeria
*Corresponding Author: Correspondence to Atanda T. Akinfenwa, Email: atatanda.pat@buk.edu.ng


Introduction: Histologically, renal cell carcinoma (RCC) is classified into predominantly clear cell carcinoma, papillary carcinoma (PC), chromophobe carcinoma, collecting ducts of Bellini carcinoma and Xp11 carcinoma.

Objectives: This study aims to evaluate histological profile and staining patterns of RCC subtypes.

Materials and Method: All cases of RCC histologically diagnosed in the pathology department of a teaching hospital in northern Nigeria in 2015 were stained using a panel of 34ẞE12, CK7, RCC-ma and CD10 antibodies.

Results: Around 23 cases of RCC, at stage III, were diagnosed. Male: Female ratio was 1:1.9 with a mean age of 40±13 years. The tumors comprised of 11 (47.8%), cases of clear cell (CC) carcinoma, 7 (30.4%) cases of PC, 4 (17.4%) cases of chromophobe carcinoma and a case (4.4%) of Xp11.2associated carcinoma. Eighty-eight percent of the CC carcinomas were RCC-ma+, 63% were CD10+ while 50% were CK7+. Seventy-five percent of the PCs were RCC-ma+ and 50% were CD10+. The chromophobe (CP) and the Xp11.2-associated carcinomas were only positive for RCC-ma and CD10. All cases of PCs, chromophobe and Xp11.2 related carcinomas were negative for CK7, and all were 34ẞE12 negative.

Conclusion: In contrast to populations with high incidence of RCC, our patients are predominantly female, younger, presented at higher stages and mostly presented with CC carcinoma. 

Citation: Akinfenwa AT, Jareenat AO, Noah DT. Histological and immunohistochemically profiles of renal cell carcinoma in northern Nigeria. Immunopathol Persa. 2018;4(1):e12. DOI: 10.15171/ ipp.2018.12.
First Name
Last Name
Email Address
Security code

Abstract View: 2584

Your browser does not support the canvas element.

PDF Download: 1617

Your browser does not support the canvas element.