Sepideh Hajian
1*1 Department of Nephrology, Ghazvin University of Medical Sciences, Qhazvin, Iran
Abstract
MicroRNAs play an important role in kidney physiology and pathology. In fact, targeting of abnormal miRNAs in patients is applicable for treatment of related disorders. It means that, administration of antagomirs as miRNA inhibitors could modulate the effect of miRNAs. Therefore it has therapeutic effect, but there is not sufficient data on the safety of these antisense oligonucleotide inhibitors. However, more studies in animal models and more clinical researches in this field are necessary.