Doaa Abd Elmaleek H. Pissar
1* 
, Sara A. Galal
1 , Mahmoud Mohamad Ahmad Omira
2, Hasan S. AL-Ghamdi
3 , Mohammad A. Alghamdi
3 , Fahad A. Alghamdi
4 , Ahmed Abdulwahab Bawahab
5 , Razan Abed A. Baloush
5 , Hussain Noorwali
5 , Mohamed Nasr
6 , Ebrahim M. Fayed
6, Moustafa A.H. El-Nawasany
6, Dina Allam Abdelmaksoud Hassan
7 , Ashraf Mohammed Said
8, Ahmed Ali Hassan Ali
8, Hossam Aladl Aladl Aladl
8, Hossam M. Farid El-Zamek
9 , Hatem Mohamed Newishy
10, Tahseen S. Mohammed
11 , Abdulkarim Hasan
12,13* 1 Dermatology and Venereology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
2 Histology Department, Faculty of Medicine Al-Azhar University, Assiut, Egypt
3 Internal Medicine Department, Division of Dermatology, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia
4 Pathology Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
5 Department of Basic Medical Sciences, Division of Pathology, College of Medicine, University of Jeddah, Jeddah, Saudi Arabia
6 Histology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
7 Histology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt
8 Internal Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
9 Clinical Pathology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
10 Medical Microbiology and Immunology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
11 Public Health and Community Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
12 Pathology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
13 Laboratory Department, Al-Baha Health Cluster, Ministry of Health, Al-Baha, Saudi Arabia
Abstract
Introduction: Several studies have suggested a potential link between Helicobacter pylori infection and psoriasis; however, the underlying mechanisms remain unclear. One proposed pathway is mediated through endothelial activation and inflammatory responses, potentially indicated by changes in E-selectin expression and related histochemical features.
Objectives: To assess the role of H. pylori infection in the expression of E-selectin in psoriasis patients and to evaluate related histological and immunohistochemical changes, aiming to provide insights into psoriasis pathogenesis and potential therapeutic targets.
Patients and Methods: A cross-sectional study was conducted on 93 patients with psoriasis, who were evaluated using the Psoriasis Area and Severity Index (PASI), H. pylori IgG antibodies, serum E-selectin levels, histopathological examination, special staining (Masson trichrome), and Ki-67 immunostaining. Patients were categorized into H. pylori-positive (n = 35) and H. pylori-negative (n = 58) groups.
Results: H. pylori-positive patients had significantly higher PASI scores (p = 0.007) and elevated E-selectin levels, particularly in severe cases (P < 0.001). Masson trichrome staining showed increased collagen in H. pylori-positive patients (64.3 ± 5%) compared to negative group (53.1 ± 2%), though not statistically significant (P = 0.152). Additionally, Ki-67 expression was significantly lower in H. pylori-positive individuals (0.51 ± 0.01%) than in H. pylori-negative ones (0.92 ± 0.01%, P = 0.04).
Conclusion: H. pylori infection may contribute to the development and exacerbation of psoriasis by promoting endothelial activation and inflammation, suggesting its potential role in disease pathogenesis.