Logo-ipp
Submitted: 10 Oct 2016
Accepted: 14 Dec 2016
ePublished: 28 Dec 2016
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Immunopathol Persa. 2017;3(2): e10-.
doi: 10.15171/ipp.2017.02
  Abstract View: 2673
  PDF Download: 1380

Original Article

Can we use serum and urine immunoglobulin levels as biomarkers in patients with glomerulonephritis? 

Sabiha Anis 1*, Jamila Parveen 1, Wajiha Musharraf 1, Ejaz Ahmed 2, Rana Muzaffar 1

1 Department of Immunology and Molecular Biology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan
2 Department of Nephrology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan
*Corresponding Author: Correspondence to Sabiha Anis, Email: Sabiha_anis@hotmail.com

Abstract

Introduction: Non-invasive biomarkers for assessing disease activity and progression are continuously being sought, but difficult to validate. For glomerulonephritis (GN), various molecules in both blood and urine are undergoing stringent research. Immunoglobulin (Ig) levels have also been sought as potential biomarkers with variable results.

Objectives: We aimed at determining the utility of serum and urine Ig levels to ascertain severity of proteinuria and renal functions in GN patients.

Materials and Methods: Blood and urine of 25 GN patients and 13 healthy controls were tested for Ig levels including IgG, IgM, IgA and IgE. The degree of proteinuria, renal functions and histopathological features were recorded from the case files of these patients.

Results: The mean serum IgM and IgA levels were significantly high in GN patients compared to controls. However, two patients had high IgM and one had high IgA levels. Three patients had low IgG levels but did not correlate with urinary loss. Moreover IgGuria was not different in patients with or without severe disease. In patients with acute GN IgMuria was more prevalent. While in chronic GN, IgAuria was more common. Mean serum IgE levels were more in healthy controls and did not correlate with renal dysfunction. However, mean IgEuria was more pronounced in patients with renal dysfunction

Conclusion: The utility of serum and urine Ig as biomarkers of disease activity and progression in GN patients is still debatable and require further studies. Abnormal levels of these proteins in blood of GN patients require further workup to rule out any concomitant pathology. 


Citation: Anis S, Parveen J, Musharraf W, Ahmed E, Muzaffar R. Can we use serum and urine immunoglobulin levels as biomarkers in patients with glomerulonephritis? Immunopathol Persa. 2017;3(2):e10. DOI: 10.15171/ipp.2017.02.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 2674

Your browser does not support the canvas element.


PDF Download: 1380

Your browser does not support the canvas element.