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Submitted: 16 Feb 2024
Accepted: 20 Apr 2024
ePublished: 25 May 2024
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Immunopathol Persa. 2025;11(1): e40634.
doi: 10.34172/ipp.2024.40634
  Abstract View: 253
  PDF Download: 52

Original

The relationship between preoperative creatinine clearance and early outcomes of adult patients undergoing deceased donor liver transplant

Soheila Milani 1 ORCID logo, Masoomeh Tabari 1 ORCID logo, Mandana Jahanian 1*, Maryam Emadzadeh 2, Monir Mirzadeh 3

1 Department of Anesthesia and Intensive Care, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
3 Organ Transplant Center, Montaserieh Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
*Corresponding Author: Mandana Jahanian, Email: ebrahimns@mums.ac.ir, Email: mandanajahanian.56@gmail.com

Abstract

Introduction: Preoperative renal dysfunction is detected in many patients undergoing liver transplants (LTs), which is significant in determining the potential surgical outcome.

Objectives: This study aimed to assess the renal dysfunction of the recipient before LT and its short-term impact after the surgery.

Patients and Methods: We reviewed the records of eligible 148 consecutive adult LT recipients from deceased donors between March 2019 and November 2021. Liver re-transplant, combined kidney-liver transplants, pre-existing kidney transplant, and renal replacement therapy before transplant were excluded. Patients who underwent LTs were divided into two groups based on their pre-LT creatinine clearance as calculated by the Cockcroft-Gault formula; group I (creatinine clearance <70 mL/min) and group II (creatinine clearance ≥ 70 mL/min). Then, the relationship between pretransplant renal function and early LT outcomes, including 3- and 12-month survival, and selected post-transplant variables were assessed.

Results: Of the 148 patients, 73 (49.3%) had preoperative creatinine clearance less than 70 mL/min. Warm ischemia time (min) was considerably higher in group II (P=0.048). However, group I had significantly delayed peak total bilirubin levels after surgery (P=0.03) as well as post-LT longer hospitalization (P<0.001) and more readmissions (P=0.002) compared to group II. No significant differences in 3- and 12-month survival rates were observed between the two groups (P=0.383 and P=0.766, respectively).

Conclusion: Renal dysfunction before LT did not significantly influence short-term survival after the surgery but did negatively affect hospital stay and readmission post-transplant.


Citation: Milani S, Tabari M, Jahanian M, Emadzadeh M, Mirzadeh M. The relationship between preoperative creatinine clearance and early outcomes of adult patients undergoing deceased donor liver transplant. Immunopathol Persa. 2024;x(x):e40634. DOI:10.34172/ ipp.2024.40634.
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