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Submitted: 25 Sep 2023
Accepted: 10 Dec 2023
ePublished: 04 Apr 2024
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Immunopathol Persa. 2024;10(2): e40617.
doi: 10.34172/ipp.2024.40617
  Abstract View: 184
  PDF Download: 64

Meta-analysis

A systematic review and meta-analysis investigating the association between constipation and colorectal cancer

Elham Mohammadzadeh 1 ORCID logo, Razieh Bagheri Shahzadeh Aliakbari 2 ORCID logo, Atieh Nouralishahi 3 ORCID logo, Amin Khameneh 4 ORCID logo, Babak Gholamine 5 ORCID logo, Alireza Baghaei 6 ORCID logo, Farzin Banei 7 ORCID logo, Shahrzad Ghaffariyan 8,9 ORCID logo, Elahe Zaremoghadam 10* ORCID logo

1 Hematology and Medical Oncology Department, Kerman Medical University, Kerman, Iran
2 College of Applied and Natural Sciences, Louisiana Tech University, Ruston, Louisiana, USA
3 Sub-Department of Operations and Analytics, Department of Management, Faculty of Environment, Science and Economy, University of Exeter, Exeter, United Kingdom
4 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
5 Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6 Dentistry School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7 Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
8 General Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
9 Guissu Research Corporation, Bandar Abbas, Iran
10 Department of Internal Medicine, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran
*Corresponding Author: Elahe Zaremoghadam, Email: dr.elahe.zaremoghadam.65@gmail.com

Abstract

Introduction: Colorectal cancer (CRC) ranks as the third most prevalent diagnosed tumor worldwide. While the association between constipation and certain tumors has been established, our study aims to examine the relationship between constipation and colorectal tumors.

Materials and Methods: This study employed a systematic review and meta-analysis following the PRISMA reporting guidelines. Searches were conducted without time restrictions until November 4, 2023, across various databases, including PubMed, Scopus, Web of Science, Cochrane, and the Google Scholar search engine. Data analysis was performed using STATA 14, and statistical significance was indicated by P<0.05.

Results: This meta-analysis included 18 studies (9 cohort studies and 9 case-control studies) with a total sample size of 1,462,496 individuals. Overall, no significant association was found between constipation and colorectal tumors (OR: 1.09, 95% CI: 0.91–1.31), colon tumor (OR: 1.09, 95% CI: 0.89–1.34), and rectal tumor (OR: 0.95, 95% CI: 0.69–1.32). Subgroup analysis, however, revealed no statistically significant association between constipation and colorectal tumors (OR: 0.93, 95% CI: 0.76–1.14), colon tumors (OR: 0.92, 95% CI: 0.75–1.13), and rectal tumor (OR: 0.92, 95% CI: 0.65–1.21) in cohort studies. In case-control studies, constipation was associated with an increased risk of colorectal tumors (OR: 1.78, 95% CI: 1.12–2.83) and colon tumors (OR: 2.32, 95% CI: 1.58–3.42), while the association between constipation and rectal tumor in case-control studies was (OR: 1.40 (95% CI: 0.62, 2.89).

Conclusion: In case-control studies, constipation emerged as a risk factor for colorectal and colon tumors, raising concerns given the high prevalence of constipation globally.

Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO (CRD42023481321) and Research Registry (UIN: reviewregistry1741) website.


Citation: Mohammadzadeh E, Bagheri Shahzadeh Aliakbari R, Nouralishahi A, Khameneh A, Gholamine B, Baghaei A, Banei F, Ghaffariyan S, Zaremoghadam E. A systematic review and meta-analysis investigating the association between constipation and colorectal cancer. Immunopathol Persa. 2024;10(2):e40617. DOI:10.34172/ ipp.2024.40617.
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