Submitted: 20 Jul 2023
Accepted: 15 Oct 2023
ePublished: 04 Dec 2023
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Immunopathol Persa. 2024;10(1): e40574.
doi: 10.34172/ipp.2023.40574
  Abstract View: 683
  PDF Download: 678


The effectiveness of gabapentin in treating overactive bladder: a quasi-experimental study

Malik Ayyad 1 ORCID logo, Omar Ayaad 2* ORCID logo, Hassan Alkhatatbeh 3 ORCID logo, Fadi Sawaqed 4, Samer Al-Rawashdeh 1, Bayan Qaddumi 5

1 Department of Urology Unit Special Surgery, Faculty of Medicine Mutah University Karak, Jordan
2 Sultan Qaboos Comprehensive Cancer Care and Research Center, Muscat, Oman
3 Department of General Surgery, Urology and Anaesthesia, Faculty of Medicine, Hashemite University, Zarqa, Jordan
4 Department of Special Surgery, Faculty of Medicine, Mu’tah University, Karak, Jordan
5 King Hussien Cancer Center, Amman, Jordan
*Corresponding Author: Omar Ayaad, Email: o.ayaad@cccrc.gov.om


Introduction: Overactive bladder (OAB) is a common condition in urology that affects individuals of various ages and genders, significantly impacting their quality of life.

Objectives: The study aimed to examine the effectiveness of gabapentin in treating OAB in Jordan.

Patients and Methods: This study was conducted at a private clinic in Jordan between 2020 and 2022. It utilized a one-group pre- and post-test design involving 50 patients. The intervention involved administering gabapentin at a daily dose of 400 mg. The effectiveness of gabapentin was evaluated using the overactive bladder symptom score (OABSS) questionnaire, administered before and after six weeks of gabapentin administration.

Results: The study sample consisted of 50 patients aged between 45 and 85 years, with a mean age of 65.2 years. After the treatment, all individual variables, such as urgency, frequency, nocturia, and urgency incontinence, showed significant reductions compared to the pre-intervention values. The mean total OABSS significantly decreased from 14.6 before to 6.8 after the intervention. The paired t test yielded a result of 9.84 with a P value of less than 0.001, indicating a statistically significant improvement.

Conclusion: The noteworthy improvement in OABSS scores, urgency, nocturia, frequency of micturition, and urge incontinence observed in this study suggests that gabapentin could have a role as a treatment option for OAB patients.

Citation: Ayyad M, Ayaad O, Alkhatatbeh H, Sawaqed F, AlRawashdeh S, Qaddumi B. The effectiveness of gabapentin in treating overactive bladder: a quasi-experimental study. Immunopathol Persa. 2024;10(1):e40574. DOI:10.34172/ ipp.2023.40574.
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