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Submitted: 18 Feb 2023
Accepted: 05 May 2023
ePublished: 16 May 2023
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Immunopathol Persa. 2023;9(2): 39503.
doi: 10.34172/ipp.2023.39503

Scopus ID: 85164608258
  Abstract View: 467
  PDF Download: 502

Original

Evaluation of the relation between cerebroplacental ratio, umbilical-cerebral ratio, and cerebro-placental-uterine ratio with the occurrence of adverse perinatal outcomes in pregnancies complicated by fetal growth restriction

Somayeh Khanjani 1 ORCID logo, Farinaz Farahbod 2 ORCID logo, Elahe Zarean 3 ORCID logo, Mohammad Javad Tarrahi 4 ORCID logo, Belgheis Mohammadi 1,5* ORCID logo

1 Department of Obstetrics and Gynecology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Obstetrics and Gynecology, Fetal Medicine Unit, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran
5 Department of Obstetrics and Gynecology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding Author: Belgheis Mohammadi, Email: mohammadi.b@skums.ac.ir, , Email: sh11090@yahoo.com

Abstract

Introduction: Fetal growth restriction (FGR) is a major obstetric complication associated with an increased risk of adverse perinatal outcomes.

Objectives: This study aimed to evaluate the relationship between Doppler parameters, including the cerebroplacental ratio (CPR), umbilicocerebral ratio (UCR), and cerebro-placental-uterine ratio (CPUR), with adverse perinatal outcomes in singleton pregnancies complicated by FGR.

Patients and Methods: This was a prospective study of 100 women with a singleton pregnancy 28 and 36.8 weeks of gestation was complicated by FGR and mild abnormalities. Feto-maternal Doppler examinations were conducted by the CPR, UCR, and CPUR parameters. Adverse outcomes were defined as Apgar score <7 at 5 minutes, preterm birth <37-week, neonatal intensive care unit (NICU) admission, fetal distress, and emergency cesarean section. These outcome parameters were checked with the results of the last ultrasound which performed 1-2 weeks before delivery.

Results: Mean umbilical artery pulsatility index (UA-PI) (1.18±0.31 versus 1.04±0.21, P=0.010) and mean uterine arteries (UtAs)-PI (1.18±0.45 versus 0.96±0.36, P=0.20) were significantly higher in pregnancies that experienced adverse perinatal outcomes than those that did not experience them. Mean CPUR (1.82±1.03 versus 2.25±0.83, P=0.039) was significantly lower in pregnancies that experienced adverse perinatal outcomes versus those that did not. In binary multivariate logistic regression analysis, CPR, UCR, and CPUR parameters were evaluated with adverse perinatal outcomes. Only CPUR had a significant relationship with adverse perinatal outcomes. CPUR had a substantial relationship with Apgar score <7 at 5 minutes (OR: 0.13; 95% CI: 0.02-0.63; P=0.012).

Conclusion: CPUR is a new Doppler ratio associated with adverse perinatal outcomes in FGR pregnancies with minimal abnormalities.


Citation: Khanjani S, Farahbod F, Zarean E, Tarrahi MJ, Mohammadi B. Evaluation of the relation between cerebroplacental ratio, umbilical-cerebral ratio, and cerebroplacental-uterine ratio with the occurrence of adverse perinatal outcomes in pregnancies complicated by fetal growth restriction. Immunopathol Persa. 2023;9(2):e39503. DOI:10.34172/ ipp.2023.39503.
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