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Submitted: 24 Jun 2022
Accepted: 16 Jan 2023
ePublished: 09 Feb 2023
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Immunopathol Persa. 2024;10(2): e34426.
doi: 10.34172/ipp.2023.34426
  Abstract View: 391
  PDF Download: 59

Original

Effect of topical aloe vera gel on gingival crevicular fluid interleukin-1 beta and interleukin-17 levels in patients with chronic periodontitis; A double-blind split-mouth randomized clinical trial

Masoumeh Faramarzi 1 ORCID logo, Azin Khorramdel 1* ORCID logo, Amir Reza Babaloo 1 ORCID logo, Mehrnoosh Sadighi 1 ORCID logo, Ali Sadaghian 2 ORCID logo

1 Department of Periodontics, Faculty of Dentistry, Tabriz University of Medical Science, Tabriz, East Azerbaijan, Iran
2 Private Practitioner, Tabriz, East Azerbaijan, Iran
*Corresponding Author: Azin Khorramdel, Email: a_khorramdel@yahoo. com, Email: dr.khorramdel@iaut.ac.ir

Abstract

Introduction: Cytokines play a prominent role in the induction of periodontal diseases. Aloe vera can ameliorate periodontal disease considering its anti-inflammatory and antibacterial effects.

Objectives: This study investigated the effect of topical aloe vera gel, associated with scaling and root planing (SRP), on interleukin-1 (IL-1) and interleukin-17 (IL-17) of gingival crevicular fluid (GCF) levels in chronic periodontitis patients.

Patients and Methods: This study recruited 20 patients diagnosed with moderate to severe chronic periodontitis (with probing pocket depths of ≥5 mm). The control group subjects underwent only SRP; the test group subjects underwent SRP, followed by topical aloe vera gel application. Periodontal clinical parameters, including probing depth (PD), clinical attachment level (CAL) and gingival index (GI), were determined; GCF levels of IL-1 and IL-17 were determined using the enzyme-linked immunosorbent assay (ELISA) at baseline and one month postoperatively.

Results: There were significant decreases in periodontal clinical parameters in both groups compared to the baseline. The test group exhibited a significant decrease in interleukin levels compared with the control group as follows; interleukin-1 beta (IL-1β) (control; 61.78±14.54, test; 43.06±10.99 ng/mL) (P<0.001), IL-17 (control; 81.33±16.66, test; 57.04±16.26 ng/mL) (P<0.001).

Conclusion: Topical aloe vera gel in combination with SRP significantly improved clinical parameters of periodontitis and decreased IL-1β and IL-17 GCF levels.

Trial Registration: The trial protocol of the present study was approved by the Iranian registry of Clinical Trials (identifier: IRCT20100412003690N11; https://en.irct.ir/trial/44975; ethical code #IR.TBZMED.REC.1398.1113).


Citation: Faramarzi M, Khorramdel A, Babaloo AR, Sadighi M, Sadaghian A. Effect of topical aloe vera gel on gingival crevicular fluid interleukin-1 beta and interleukin-17 levels in patients with chronic periodontitis; A double-blind split-mouth randomized clinical trial. Immunopathol Persa. 2024;10(2):e34426. DOI:10.34172/ ipp.2023.34426.
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