Submitted: 26 Apr 2022
Accepted: 31 May 2022
ePublished: 16 Aug 2022
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Immunopathol Persa. 2023;9(2): 32410.
doi: 10.34172/ipp.2022.32410

Scopus ID: 85164561388
  Abstract View: 1348
  PDF Download: 480


Is there a change in platelet indices among pregnant with antiphospholipid syndrome?

Shaima K. Harmoosh 1 ORCID logo, Wassan Nori 2* ORCID logo, Roaa Mokram Hamed 3,4 ORCID logo

1 Yarmouk Teaching Hospital/ infertility clinic, Baghdad, Iraq
2 Department of Obstetrics and Gynecology, Faculty of Medicine, Mustansiriyah University, Baghdad, Iraq
3 The National Center of Hematology, Mustansiriyah University, Baghdad, Iraq
4 National University of Science and Technology, Nasiriyah, Iraq
*Corresponding Author: Wassan Nori, Email: Dr.wassan76@uomustansiriyah.edu.iq


Introduction: Recurrent pregnancy loss (RPL) is a common obstetrical complication, but 50% of cases have an undetermined etiology. Antiphospholipid syndrome (APL) is an autoimmune disease that has been linked to RPL. Platelet abnormalities, particularly thrombophilia, have been linked to RPL.

Objectives: This study examined the change in platelet parameters, specifically, platelet count, mean platelet volume (MPV), and platelet distribution width (PDW), in patients presenting with RPL caused by APL.

Patients and Methods: Fifty women with a confirmed diagnosis of APL syndrome with a history of RPL were assigned as a study group, and 50 women who gave birth without RPL were healthy controls. Pregnant women were recruited from Al Yarmouk teaching hospital. Personal data were collected through direct interviews with patients, followed by blood samples that were analyzed for complete blood counts and platelet indices.

Results: Both platelet count and PDW showed a significant correlation with the number of pregnancy losses; Pearson’s correlation coefficient was (r=0.74, and r=0.59) for platelet count and PDW. The receiver operating characteristic (ROC) calculated a platelet count cut-off value of 230, with 88% sensitivity and 84% specificity, an area under the curve (AUC) of 0.89, and a P value of 0.001. The PDW had a cut-off value of 13.6 fl/L, associated with 88% sensitivity, 80% specificity, AUC=0.87, and a P value <0.001.

Conclusion: Platelet indices may aid gynecologists in low-resource settings in predicting high-risk pregnancies deemed to suffer from RPL.

Citation: Harmoosh SK, Nori W, Hamed RM. Is there a change in platelet indices among pregnant with antiphospholipid syndrome? Immunopathol Persa. 2023;9(2):e32410. DOI:10.34172/ ipp.2022.32410.
First Name
Last Name
Email Address
Security code

Abstract View: 1299

Your browser does not support the canvas element.

PDF Download: 480

Your browser does not support the canvas element.