Logo-ipp
Submitted: 19 Sep 2015
Accepted: 27 Dec 2015
ePublished: 25 Jan 2016
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Immunopathol Persa. 2016;2(1): e08-.
  Abstract View: 2131
  PDF Download: 1095

Case Report

Non-amyloid deposits glomerulopathy with multiple myeloma; a rare presentation

Kawtar Alaoui Sekkouri 1, Fatima Zahra Batta 1, Khadija Alaoui Belghiti 1, Hanae Alaoui 1, Hadj Sadek Bahae 1, Mohamed Arrayhani 1, Taoufik Taoufik 2, Tarik Sqalli Houssaïni 2*

1 Department of Nephrology, CHU Hassan II, Fez, Morocco
2 Laboratory of Pathology, CHU Hassan II, Fez, Morocco
*Corresponding Author: Correspondence to Tarik Sqalli Houssaïni, Email: tariksqalli@hotmail.com

Abstract

Renal complications in multiple myeloma are common. The occurrence of non-amyloid deposits glomerulopathy is rare. We report an exceptional non-amyloid deposits glomerulopathy in a patient followed for multiple myeloma in complete remission. A 70-year-old male patient, followed for lambda light chains multiple myeloma, and treated according to the protocol “Alexanian” with a complete remission at the end of treatment. After one year of follow-up, a deep pure nephrotic syndrome occurred. Renal biopsy was then conducted. It included 10 glomeruli, all with pseudo-amyloid deposits, amorphous and stifling tuft. Congo-red was negative. Immunofluorescence objectified a glomerular and mesangial intense, diffuse and global IgG deposits. The electron microscopic examination was not conducted. Kidney damage in multiple myeloma include tubulointerstitial nephropathy and immunoglobulin glomerulopathy, which amyloidosis deposits and Randall syndrome. The clinic context, as well as the appearance in optical microscopy of renal fragment moving towards renal amyloidosis. Paradoxically, the Congo-red staining was negative, in favor to a non-amyloid deposits glomerulopathy. An electron microscopic examination is needed to highlight the fibrillar or microtubular deposits. The occurrence of non-amyloid deposits glomerulopathy in multiple myeloma is exceptional. The study by light microscopy, immunofluorescence and electron microscopy especially makes it easy to diagnose. 

Citation: Alaoui Sekkouri K, Batta FZ, Alaoui Belghiti K, Alaoui H, Bahae HS, Arrayhani  M, et al. Non-amyloid deposits glomerulopathy with multiple myeloma; a rare presentation. Immunopathol Persa. 2016;2(1):e08.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 2132

Your browser does not support the canvas element.


PDF Download: 1095

Your browser does not support the canvas element.