Abstract
Introduction: Identifying the incidence of pathogen colonizations in pregnant women with preeclampsia can be effective in providing proper treatment and reducing complications.
Objectives: We evaluated the frequency and association between positive rectovaginal culture of group B Streptococcus (GBS) and positive Helicobacter pylori serology with preeclampsia in two groups of pregnant women (with and without preeclampsia).
Patients and Methods: The present case-control study included pregnant women with preeclampsia and healthy pregnant controls during 2019-2020. Blood and rectovaginal samples were obtained and the data were statistically analyzed using SPSS software.
Results: Fifty-four people were included in the study. The mean gestational age was 36 ± 3.4 months in the preeclampsia group and 37 ± 2.9 months in the control group. There was no significant relationship between preeclampsia and H. pylori-positive serology (P=0.84). Additionally, the association between positive H. pylori serology and the severity of preeclampsia was not significant (P=0.15). However, there was a significant relationship between positive H. pylori tests with early- and late-onset preeclampsia (P=0.04). However, there was no statistically significant relationship between the positive rectovaginal culture of GBS and preeclampsia, the severity of preeclampsia, the onset time, or the weight of newborns.
Conclusion: There was a significant relationship between H. pylori infection and late-onset preeclampsia in preeclamptic mothers. H. pylori screening and eradication therapy before pregnancy can prevent preeclampsia and its serious consequences in both the mother and the fetus.