Abstract
Introduction: Renal colic is the most common clinical manifestation of urinary stones.
Objectives: This study was aimed to compare the effect of intranasal ketamine versus intravenous morphine on renal colic.
Patients and Methods: In this clinical trial study, 100 patients with renal colic were entered into the study and randomly divided into two groups. Patients in treatment group received intranasal ketamine (1.5 mg/kg) and the other group was given intravenous morphine (0.1 mg/kg). The pain was measured at 0, 5, 15, 30 and 60 minutes after therapy.
Results: In this study, 32% of patients were female and 68% were male. In addition, the difference between the initial pain with the pains at all subsequent times was significant in the two groups (P<0.001). The duration of the ketamine effect to control pain was longer; since, with the administration of morphine, a faster effect on pain relief was achieved.
Conclusion: Low-dose ketamine is considered as an analgesic with low side effects, with simple and uncomplicated usage that reduces the risk of the needle stick in pre-hospital conditions. Therefore, intravenous (IV) morphine has a faster effect; therefore its administer in patients with severe pain should be given priority.
Trial Registration: The trial protocol was approved in the Iranian Registry of Clinical Trial (identifier: IRCT20171229038132N1; https://irct.ir/trial/28821, ethical code; IR.ZAUMS.REC.1396.271).