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Submitted: 11 Aug 2021
Accepted: 13 Dec 2021
ePublished: 20 Jan 2022
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Immunopathol Persa. 2023;9(1): e29262.
doi: 10.34172/ipp.2022.29262
  Abstract View: 123
  PDF Download: 122

Review

Behcet’s disease; a narrative review with a focus on autoimmunity processes in involved organs

Zeynab Ebrahimi Fard 1 ORCID logo, Javad Balasi 1 ORCID logo, Atiyeh Kimiaefar 1 ORCID logo, Kimia Jazi 2 ORCID logo, Zahra Hajrezaei 2 ORCID logo, Jafar Karami 3 ORCID logo, Seyyed Mohsen Banitaba 1, Maryam Masoumi 4* ORCID logo

1 Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2 Student Research Committee, Faculty of Medicine, Medical University of Qom, Qom, Iran
3 Department of Laboratory Sciences, Khomein University of Medical Sciences, Khomein, Iran
4 Clinical Research of Development Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran
*Corresponding Author: Correspondence to Maryam Masoumi, Email: dr.masoumi2017@gmail. com, sshamsmed@gmail.com, , Email: mmasoomi@muq.ac.ir

Abstract

Behcet’s disease (BD) is an autoimmune and inflammatory disease that is mainly characterized by involvement of the gastrointestinal tract, cardiovascular system, genital tract and joints. The disease is more common in the Middle Eastern and Far Eastern countries and the frequency of recurrences and attacks varies among populations. Although the pathogenesis is not fully understood, there is evidence to suggest that immunodeficiency and specific patterns of production of immune regulatory mediators are important. Impaired autoimmune and inflammatory cells, target endothelial cells and prompt vasculitis in the involved organs. Elucidating the immunological mechanism of BD can facilitate the development of new therapies and therapeutic immunoregulatory interventions to prevent possible complications. New therapies, including manipulation of immune-regulating mediators such as interferon-alpha antagonists, have shown promising results in patients with BD. This review aims to consider the role of auto-inflammatory and autoimmune processes and related factors which give rise to the different manifestations of the disease in each involved organ.

Citation: Ebrahimi Fard Z, Balasi J, Kimiaefar A, Jazi K, Hajrezaei Z, Karami J, Banitaba SM, Masoumi M. Behcet’s disease; a narrative review with a focus on autoimmunity processes in involved organs. Immunopathol Persa. 2023;9(1):e29262. DOI:10.34172/ ipp.2022.29262.
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