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Submitted: 12 Jul 2021
Accepted: 05 Aug 2021
ePublished: 09 Feb 2022
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Immunopathol Persa. 2024;10(2): e28262.
doi: 10.34172/ipp.2022.28262

Scopus ID: 85197799282
  Abstract View: 1008
  PDF Download: 173

Original

The therapeutic effects of chicory seed aqueous extract on cardio-metabolic profile and liver enzymes in nonalcoholic fatty liver disease; a double blind randomized clinical trial

Maral Marzban 1 ORCID logo, Mohsen Bahrami 1 ORCID logo, Mohammad Kamalinejad 2 ORCID logo, Maryam Tahamtan 3 ORCID logo, Narjes Khavasi 1,4 ORCID logo, Mahdie Haji Monfared 5 ORCID logo, Maryam Jameshorani 4* ORCID logo

1 Department of Persian Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
2 Department of Pharmacognosy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Cardiovascular Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4 Zanjan Metabolic Disease Research Center, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
5 Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
*Corresponding Author: Maryam Jameshorani, Email: dr.shirinjameshorani@zums.ac.ir

Abstract

Introduction: As diabetes and obesity increase worldwide, non-alcoholic fatty liver disease (NAFLD) becomes a more worrying health threat.

Objectives: This study was designed to assess the impacts of chicory seed aqueous extract on the treatment of NAFLD.

Patients and Methods: Around 60 patients with NAFLD who referred to Zanjan Metabolic Disease Research Center between March 2016 and April 2017 were allocated into treatment and placebo groups, randomly. The participants in the treatment group (n=30) were scheduled to consume 8 ml of chicory seed syrup (made by soaking 100 g of dried seeds in one liter of boiling water) twice daily for 12 weeks. The control group’s patients received placebo syrup with an identical figure and flavor and also with the same prescript. The analysis of covariance (ANCOVA) test, chi-square test, independent t-test and paired t test were applied for analysis of data. From the point of statistical view, P < 0.05 was considered significant.

Results: The body mass index (BMI), liver enzymes, fasting blood sugar test (FBS), HbA1c, fatty liver grading and all the indices of lipid profile decreased significantly (all P values < 0.001) in the chicory group. The shifting change in fatty liver grading was also striking in treatment group’s patients compared to controls.

Conclusion: The findings of this study support the application of chicory seed in the treatment of NAFLD due to the ameliorative effects on the metabolic indices of the disease.

Trial Registration: This clinical trial protocol has been registered in Iranian Registry of Clinical Trial (identifier: IRCT2016061228411N1; https://en.irct.ir/trial/23063, ethical code #IR.ZUMS.REC.1395.195).



Citation: Marzban M, Bahrami M, Kamalinejad M, Tahamtan M, Khavasi N, Haji Monfared M, Jameshorani M. The therapeutic effects of chicory seed aqueous extract on cardiometabolic profile and liver enzymes in nonalcoholic fatty liver disease; a double blind randomized clinical trial. Immunopathol Persa. 2024;10(2):e28262. DOI:10.34172/ ipp.2022.28262.
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