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Submitted: 29 Nov 2015
Accepted: 01 Jan 2016
ePublished: 03 Jan 2016
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Immunopathol Persa. 2016;2(1): e06-.
  Abstract View: 2424
  PDF Download: 1334

Review

Use of rituximab in immunological disorders 

Rubina Naqvi 1*

1 Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan
*Corresponding Author: Correspondence to Prof. Rubina Naqvi, Email: rubinanaqvi@gmail.com

Abstract

Over last few decades multiple avenues in immunology research has been opened. Recent studies have highlighted role of B cells in pathogenesis of many immunological disorders. B cells or B lymphocytes are a type of lymphocyte in the humoral immunity of the adaptive immune system that makes antibodies against invading pathogens such as viruses. Rituximab, an antibody against the B cell-expressed CD20 antigen, was the first monoclonal employed for the treatment of a glomerular disease and some other immune mediated diseases. Its uses in different immunological disorders including focal segmental glomerulosclerosis (FSGS), membranous nephritis, lupus nephritis, cryoglobulinemias, thrombotic thrombocytopenic purpura, anti-neutrophilic cytoplasmic antibody associated vasculitis, C1q nephropathy, antibody mediated renal transplant rejections, recurrent glomerular diseases in renal allograft, rheumatoid arthritis and other autoimmune neurological and muscular disorders are reviewed here in this article. Multiple searches made on related subject and articles discussing the use of rituximab in any of these diseases were reviewed for the preparation of current review. Dosage, mode of action and adverse effects of drug also been highlighted briefly. 

Citation: Naqvi R. Use of rituximab in immunological disorders. Immunopathol Persa. 2016;2(1):e06.
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