Logo-ipp
Submitted: 06 Apr 2021
Accepted: 10 Jul 2021
ePublished: 03 Aug 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Immunopathol Persa. 2022;8(1): e6.
doi: 10.34172/ipp.2022.06
  Abstract View: 45
  PDF Download: 23

Original

Evaluation of changes in plasma vitamin C levels in brain-dead organ donors

Soheila Milani 1 * ORCID logo, Amin Dalili 2 ORCID logo, Mostafa Sadeghi 3 ORCID logo, Neda Nabizadeh 4

1 Department of Anesthesia and Intensive Care, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Operating Room, Montaserieh Dialysis and Transplant Center, Mashhad University of Medical Sciences, Mashhad, Iran
4 Department of Anesthesia and Intensive Care, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
*Correspondence to Soheila Milani, Email; drmilanis7@gmail.com, ebrahimns@mums.ac.ir

Abstract

Introduction: Inflammatory events after brain death (BD) generally influence the quality of donated organs and adversely affect the outcome of transplant surgeries. Vitamin C is a natural organic compound with potent antioxidant properties. Changes in serum levels of vitamin C (ascorbic acid) following BD are still unknown.

Objectives: This study aimed to assess the changes in serum vitamin C levels in brain dead donors in the time elapsed between BD diagnosis and at once before procurement procedure of donated organs.

Patients and Methods: In this experimental study, serum vitamin C levels were measured in 37 brain-dead donors (BDDs) at two time points, primarily on admission (R1) and just before organ procurement (R2). The difference between mean values of R1-R2 was analyzed according to the parameters of brain dead donor’s, which consisted of gender, cause of BD, and type of blood group.

Results: A total of 37 BDDs (62.2% male) with a mean age of 26.48±18.1 years were included. Time interval between the two samplings was 40.09±12.10 hours. Overall, there was a statistically significant difference between serum ascorbic acid (AA) levels at admission (R1) and immediately before organ procurement (R2) (P=0.016). However, in terms of the cause of BD and blood type, no significant difference in serum AA at the two-time points was detected (P=0.85 and P=0.79 respectively).

Conclusion: Significant differences were observed between serum vitamin C levels in the duration between BD diagnosis and immediately before procurement surgery. Therefore, determining the most effective dose of vitamin C supplementation and the best time to administer it to the patients is highly recommended for future studies.

Keywords: Brain death, Transplantation, Ascorbic acid, Reactive Oxygen species, Antioxidant
Citation: Milani S, Dalili A, Sadeghi M. Evaluation of changes in plasma vitamin C levels in brain-dead organ donors. Immunopathol Persa. 2022;8(1):e06. DOI:10.34172/ipp.2022.06.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 45

Your browser does not support the canvas element.


PDF Download: 23

Your browser does not support the canvas element.