Abstract
Introduction: Acute cholecystitis is one of the most common gallbladder diseases. Surgical operation is still the main treatment of biliary diseases, but there may be required a period of stabilization in the hospital before cholecystectomy. Infected bile in different studies has been reported from 50% to 75%. Therefore, identification of microbial mass followed by antibiotic treatment for this disease is important.
Objectives: In this study, bacterial spectrum in patients undergoing cholecystectomy was evaluated based on clinical symptoms and laboratory parameters.
Patients and Methods: In this prospective cross-sectional study, all patients requiring cholecystectomy were enrolled in the study. In the study, the data on age, gender, clinical signs of all patients and laboratory results and biliary liquid experiments were collected.
Results: Fourteen cases including 13 cases of E. coli and a Staphylococcus strain had positive cultures. No significant correlation was detected between gender, fever, vomiting, tenderness right upper quadrant (RUQ), anorexia, jaundice, age group and microbial growth (P>0.05). Moreover, no significant correlation between laboratory parameters such as white blood cell (WBC), total bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase, amylase and microbial growth was seen (P>0.05).
Conclusion: Bile culture was positive in 14% of patients undergoing cholecystectomy and E. coli was the predominant microorganism. Frequency of positive culture is low and has no relationship with demographic, clinical and laboratory factors and could not have a significant effect on the occurrence of postoperative complications; therefore, it seems that the administration of antibiotics before surgery is not necessary.