Submitted: 21 May 2021
Accepted: 31 Jul 2021
ePublished: 08 Aug 2021
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Immunopathol Persa. 2022;8(1): e19.
doi: 10.34172/ipp.2022.19

Scopus ID: 85119214773
  Abstract View: 1630
  PDF Download: 1299


Lung cancer risk and the inhibitors of angiotensin converting enzyme; an updated review on recent evidence

Maryam Khosravian 1 ORCID logo, Mahnaz Momenzadeh 2* ORCID logo, Farzad Koosha 3 ORCID logo, Niloufar Alimohammadi 4 ORCID logo, Neda Kianpour 5 ORCID logo

1 Department of Internal Medicine I, Martin Luther University, Halle, Germany
2 Nikan Research Institute, Isfahan, Iran
3 Department of Oral Biology and Pathology, School of Dental Medicine, State University of New York at Stony Brook, New York, USA
4 Department of Medicine, New York University School of Medicine, New York, New York, USA
5 Department of Biotechnology, Biohouse, Inland Norway University of Applied Sciences, Hamar, Hedmark, Norway
*Corresponding Author: *Correspondence to Mahnaz Momenzadeh, Email: Mahnazmomenzadehf@gmail. com, , Email: Mahnaz.momenzadeh@ pharm.mui.ac.ir


The renin-angiotensin-aldosterone system (RAAS) has a significant act in the pathology of blood pressure and cancer. One of the dominant sections of angiotensin II (Ang II) and angiotensin-converting enzyme (ACE) expression generation in the human body is the capillary veins in the lung. Changes in the expression of RAAS were revealed to be included in several lung diseases. There are several studies on the anticancer effect of ACE inhibitors; however, Hicks and colleagues reported an augmented risk of 14% for advancing lung cancer for patients consuming ACE inhibitors against angiotensin receptor blockers (ARBs) administration. Several lines of evidence indicated that ARB users have a lower risk of tumor progression and metastasis and progression of lung cancer. This review has surveyed some studies about the study by Hicks et al with conflicting results. Some Hicks’s study limitations are summarized here such as genetic effects, comparative study, residual confounding factors such as smoking, detection bias owing to cough, and socio-economic status. It is suggested some natural alternatives to ACE Inhibitors in here.

Citation: Khosravian M, Momenzadeh M, Koosha F, Alimohammadi N, Kianpour N. Lung cancer risk and the inhibitors of angiotensin converting enzyme; an updated review on recent evidence. Immunopathol Persa. 2022;8(1):e19. DOI:10.34172/ ipp.2022.19.
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