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Submitted: 25 Apr 2021
Accepted: 10 Jul 2021
ePublished: 30 Jul 2021
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Immunopathol Persa. 2024;10(1): e25261.
doi: 10.34172/ipp.2022.25261
  Abstract View: 701
  PDF Download: 182

Case Report

Duodenal monomorphic epitheliotropic intestinal T cell lymphoma along with unpredictable intestinal Epstein-Barr virus infection; a rare newly redefined entity in a rare site and review of literature

Somaia Ahmed Saad El-Din 1,2* ORCID logo, Khalid Al Hashmi 3, Khaled Hamad 4, Fahad Al-Ghafri 3

1 Pathology Laboratory, Armed Forces Hospital, Muscat, Oman
2 Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt
3 Medical Oncology Department, Armed Forces Hospital Muscat, Oman
4 Medical Department, Armed Forces Hospital Muscat, Oman
*Corresponding Author: Somaia Ahmed Saad El-Din, Email: drsomaia2005@gmail. com, , Email: somiasd12@med.asu.edu.eg

Abstract

Introduction: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), previously known as type II enteropathy associated T-cell lymphoma (EATL), was redefined by the WHO (2016) as separate entity from the celiac disease-associated lymphoma. It is an extremely rare and highly aggressive peripheral T-cell lymphoma. It mainly involves jejunum and ileum and rarely duodenum.

Case Presentation: This was a 38-year-old male patient presented by daily vomiting related to meals for 8 months along with generalized colicky abdominal pain associated with constipation and marked weight loss. Upper endoscopy showed large ulcerated mass at the third part of the duodenum. Histopathological examination showed the diffuse malignant lymphoid infiltrate with morphology and immunophenotyping consistent with MEITL associated with unpredictable Epstein-Barr virus (EBV) in intestinal epithelial cells. The patient underwent five cycles of chemotherapy (cyclophosphamide, hydroxydaunorubicin, oncovin and prednisone) followed by duodenectomy.

Conclusion: This case represents a rare newly redefined lymphoma entity in a rare site associated with unpredictable non-neoplastic epithelial EBV infection, which proved to be oncogenic agent involved in various hematopoietic and other neoplasms with unclear relationship to the development of this MEITL.


Citation: Saad El-Din SA, Al Hashmi K, Hamad K, Al-Ghafri F. Duodenal monomorphic epitheliotropic intestinal T cell lymphoma along with unpredictable intestinal EpsteinBarr virus infection; a rare newly redefined entity in a rare site and review of literature. Immunopathol Persa. 2024;10(1):e25261. DOI:10.34172/ ipp.2022.25261.
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