Logo-ipp
Submitted: 14 Apr 2021
Accepted: 30 Jul 2021
ePublished: 11 Aug 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Immunopathol Persa. 2022;8(1): e15.
doi: 10.34172/ipp.2022.15
  Abstract View: 33
  PDF Download: 14

Original

Investigating the effect of captopril on reducing the severity of symptoms of acute respiratory distress syndrome in rats

Marjan Golshani 1 ORCID logo, Mohammad Hossein Sanei 2 ORCID logo, Maryam Jabbari 3 * ORCID logo

1 Associate Professor of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Associate Professor of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
3 Resident of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
*Correspondence to Maryam Jabbari; Email: jabbari.mary@gmail.com

Abstract

Introduction: Acute respiratory distress syndrome (ARDS) occurs when fluid builds up in the tiny, elastic air sacs (alveoli) in the lungs.

Objectives: This study aimed to investigate the effect of captopril in reducing the symptoms of ARDS induced by oleic acid in experimental rats.

Materials and Methods: This experimental study was conducted on 14 Wistar male rats of 6-7 weeks weighing 200-250 g. In the first group, they received 1.25 mg/kg of captopril daily in glucose solution for one week, but the second group did not. After one week, these rats were anesthetized by 5% isoflurane respiration and oleic acid (0.1 mg/kg) was injected intraperitoneal for ARDS induction. During the first 6 hours after starting ARDS, the rats were randomly selected and after anesthesia with ether and autopsy, they were cut and the lung histology was conducted.

Results: Intensity of lung tissue edema in the group receiving captopril (Cap) was 2.83 ± 0.41 and in the captopril group with oleic acid (Cap+OA) was 2.50±0.55. Additionally, 83.3% of the rats had severe pulmonary edema in the OA group which was statistically significant (P=0.003). The “severity of inflammation and bleeding” in the OA+Cap group was significantly less than OA group (P=0.026).

Conclusion: Captopril can play a significant role in reducing the damage of the lung tissue and severity of tissue edema and inflammation and bleeding. Therefore, it may be possible to use this drug in human samples with acute respiratory distress syndrome to prevent further damage.


Keywords: Captopril, Acute respiratory distress syndrome, Oleic acid
Citation: Golshani M, Sanei MH, Jabbari M. Investigating the effect of captopril on reducing the severity of symptoms of acute respiratory distress syndrome in rats. Immunopathol Persa. 2022;8(1):e15. DOI:10.34172/ ipp.2022.15.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 33

Your browser does not support the canvas element.


PDF Download: 14

Your browser does not support the canvas element.