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Submitted: 07 Apr 2021
Accepted: 01 Dec 2021
ePublished: 17 Apr 2022
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Immunopathol Persa. 2024;10(1): e24257.
doi: 10.34172/ipp.2022.24257
  Abstract View: 431
  PDF Download: 182

Original

Comparison of ultrasound findings and fine needle aspiration results between anti-thyroid peroxidase positive and negative patients with nodular goiters

Mahsa Malekian 1 ORCID logo, Nasser Aghamohammadzadeh 1 ORCID logo, Farzad Najafipour 1 ORCID logo, Reza Javad-Rashid 2 ORCID logo, Javad Jalili 3 ORCID logo, Monireh Halimi 4 ORCID logo, Farshid Bozorgi 4 ORCID logo, Jalil Houshyar 1* ORCID logo

1 Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Radiology Department, Medical Radiation Sciences Research Group, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
3 Radiology Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4 Department of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Jalil Houshyar, Email: hoshyarj2@gmail.com

Abstract

Introduction: Ultrasonography is an optimal approach for thyroid gland evaluation, nodule detection and cancer risk assessment in patients with thyroid nodules. Almost all patients with Hashimoto’s thyroiditis have high levels anti-thyroid peroxidase (anti-TPO) antibodies.

Objectives: This study aimed to evaluate the relationship between ultrasonography and fine needle aspiration (FNA) results in anti-TPO antibodies positive and negative patients with nodular goiters.

Patients and Methods: This cross-sectional study included 128 patients with nodular goiters, referred to endocrinology clinic of imam Reza hospital, Tabriz, Iran. Anti-TPO levels above and below 16 IU/mL were considered as positive and negative, respectively. All patients underwent thyroid ultrasonography, and eligible nodules were subjected to FNA.

Results: Of 128 patients, 33.6% and 66.4% were anti-TPO positive and negative, respectively. FNA was conducted on 196 nodules. A significant relationship was observed between sonographic and FNA results in low and intermediate-suspicion nodules. Chronic lymphocytic thyroiditis (CLT) was more frequently reported in low-suspicion nodules of the anti-TPO positive group (P≤0.0001). In addition, in intermediate-suspicion nodules, CLT was reported in 33.3% of patients in the anti-TPO positive group (P=0.026). No significant difference was observed between other nodules.

Conclusion: Based on our findings, when a nodule is classified in low or intermediate-suspicion categories, the possibility of CLT following FNA is significantly higher in the anti-TPO positive group, compared to the anti-TPO negative group.


Citation: Malekian M, Aghamohammadzadeh N, Najafipour F, Javad-Rashid R, Jalili J, Halimi M, Bozorgi F, Houshyar J. Comparison of ultrasound findings and fine needle aspiration results between anti-thyroid peroxidase positive and negative patients with nodular goiters. Immunopathol Persa. 2024;10(1):e24257. DOI:10.34172/ ipp.2022.24257.
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