Seyed Seifollah Beladi-Mousavi
1, Khadije Hajibabaei
2, Azam Hamledari
3, Mohammad-Reza Tamadon
4, Mohammad-Reza Ardalan
5*1 Chronic Renal Failure Research Center, Ahvaz Junishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Chemistry, Faculty of Sciences, Najafabad Branch, Islamic Azad University, Najafabad, Iran
3 Hourtash Food Laboratory, Najafabad, Isfahan, Iran
4 Department of Nephrology, Semnan University of Medical Sciences, Semnan, Iran
5 Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Immunotoxins are mostly contain a monoclonal antibody part linked to a toxin, generally of bacterial or plant origin. The antibody gives specificity (ability to identify and react with the target), while the toxin gives cytotoxicity (ability to kill the target). In this paper, we will explain about the different parts of immunotoxins, linkage methods of the antibody to the toxin and their application in treatment of cancer and other diseases. This review will help physicians better inform patients about the potential benefits of these experimental treatments.