Logo-ipp
Submitted: 20 Dec 2020
Accepted: 19 Feb 2021
ePublished: 14 Apr 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Immunopathol Persa. 2022;8(1): e8.
doi: 10.34172/ipp.2022.08
  Abstract View: 40
  PDF Download: 14

Original

The effect of vitamin E and vitamin C in patients with COVID-19 pneumonia; a randomized controlled clinical trial

Atousa Hakamifard 1 ORCID logo, Rasool Soltani 2 ORCID logo, Ahmadreza Maghsoudi 3 * ORCID logo, Ali Rismanbaf 2, Marzieh Aalinezhad 4, Mohammad Javad Tarrahi 5, Sanaz Mashayekhbakhsh 6, Kian Dolatshahi 6

1 Department of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2 Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
3 Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
4 Department of Radiology, Isfahan University of Medical Sciences, Isfahan, Iran
5 Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
6 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
*Correspondence to Ahmadreza Maghsoudi, Email: ahmaghsoudi@med. mui.ac.ir, dr_maghsoudi_md@ yahoo.com

Abstract

Introduction: Cytokine storm and oxidative stress play a key role in the pathogenesis of coronavirus disease 2019 (COVID-19). Vitamins C and E are two known antioxidants with possible theoretical beneficial effects in COVID-19 patients.

Objectives: This study aimed to clinically evaluate the effects of the combination of these agents as adjunctive therapy with the standard treatment in the outcome of COVID-19 patients.

Patients and Methods: Hospitalized non-severe COVID-19 patients were randomly divided into two groups of intervention (n=38) and control (n=34) to receive either oral vitamin C 1000 mg daily plus oral vitamin E 400 IU daily in addition to the national standard treatment regimen (hydroxychloroquine) or standard regimen alone, respectively, during the hospitalization period until hospital discharge or ICU admission. The clinical response of patients at the end of treatment (either cure, improvement, or failure), the duration of hospitalization, and the mortality rate were recorded and compared between the groups.

Results: During the study, three patients in the intervention group (7.89%) and five patients in the control group (14.71%) had treatment failure, while all other patients had clinical improvement (P = 0.380). The duration of hospitalization was shorter in the intervention group (7.95 ± 3.18 days) compared to the control group (8.03 ± 2.83 days); however, the difference was not statistically significant (P = 0.821). Furthermore, no patients in both groups died during the study.

Conclusion: The combination of oral vitamins C (1000 mg daily) and E (400 IU daily) has no beneficial effect in COVID-19 patients.

Trial Registration: Registration of trial protocol has been approved in Iranian registry of clinical trials (identifier: IRCT20180425039414N3; https://www.irct.ir/trial/48083, ethical# IR.MUI.MED.REC.1399.047).


Keywords: COVID-19, Vitamin C, Vitamin E, Clinical trial
Citation: Hakamifard A, Soltani R, Maghsoudi A, Rismanbaf A, Aalinezhad M, Tarrahi MJ, Mashayekhbakhsh S, Dolatshahi K. The effect of vitamin E and vitamin C in patients with COVID-19 pneumonia; a randomized controlled clinical trial. Immunopathol Persa. 2022;8(1):e08. DOI:10.34172/ ipp.2022.08.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 40

Your browser does not support the canvas element.


PDF Download: 14

Your browser does not support the canvas element.