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Submitted: 24 Jan 2021
Accepted: 24 Mar 2021
ePublished: 31 Jul 2021
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Immunopathol Persa. 2022;8(1): e3.
doi: 10.34172/ipp.2022.03
  Abstract View: 37
  PDF Download: 16

Original

Evaluation of mast cell count in oral and cutaneous lichen planus lesions

Mohammad Koochak Dezfouli 1,2 ORCID logo, Fatemeh Montazer 3 ORCID logo, Atena Shiva 1,2 ORCID logo, Mahmood Moosazadeh 4 ORCID logo, Maryam Biglari Abhari 5 ORCID logo, Hadi Alidoust 6 ORCID logo, Maryam Zamanzadeh 1,2 * ORCID logo

1 Department of Oral and Maxillofacial Pathology, School of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
2 Dental Research Center, Mazandaran University of Medical Sciences, Sari, Iran
3 Dermatopathologist, Department of Pathology, Iran University of Medical Sciences, Tehran, Iran
4 Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
5 Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Community and Family Medicine Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
6 Dentist, Tehran, Iran
*Correspondence to Maryam Zamanzadeh, Email: mzamanzadeh@mazums.ac.ir, zamanzadehmaryam@gmail. com

Abstract

Introduction: Lichen planus (LP) is a relatively common chronic mucocutaneous disorder diagnosed based on clinical manifestations and histopathological findings. Mast cells (MCs) are multifunctional immune cells that are involved in the pathogenesis of LP by releasing certain chemical mediators.

Objectives: The purpose of this comparative study was to estimate the number of intact (granulated), degranulated and total MCs in oral lichen planus (OLP) and cutaneous lichen planus (CLP) lesions.

Patients and Methods: The present descriptive-analytical and cross-sectional study was conducted on 125 LP blocks, including 40 OLP samples and 85 CLP samples. The mean number of granulated, degranulated and total MCs were counted under light microscope (×100 and ×400). Data were analyzed by SPSS version 24 software using Mann-Whitney U and Pearson’s chi-square tests.

Results: The mean total MC count was 14.92 ± 3.90 in OLP samples and 14.04 ± 5.60 in CLP samples respectively which was not statistically significant. The mean granulated MC count in CLP (10.53 ± 5.70) was higher than in OLP (4.34 ± 3.46) (P<0.001). The mean degranulated MC count in OLP (10.57 ± 2.99) was higher than in CLP (3.51 ± 2.72) (P<0.001).

Conclusion: No statistically significant difference was observed in the total MC count between OLP and CLP; however the difference in the degranulated MC count was detected between OLP and CLP. Despite the homogeneity in the total MC count, the MCs appear to play different pathological roles in OLP and CLP.

Keywords: Mast cells, Oral lichen planus, Cutaneous lichen planus
Citation: Koochak Dezfouli M, Montazer F, Shiva A, Moosazadeh M, Biglari Abhari M, Alidoust H, Zamanzadeh M. Evaluation of mast cell count in oral and cutaneous lichen planus lesions. Immunopathol Persa. 2022;8(1):e03. DOI:10.34172/ ipp.2022.03.
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