Logo-ipp
Submitted: 14 Oct 2020
Accepted: 03 Feb 2021
ePublished: 22 Feb 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Immunopathol Persa. 2022;8(1): e16.
doi: 10.34172/ipp.2022.16

Scopus ID: 85120089055
  Abstract View: 2479
  PDF Download: 1374

Original

Serum concentrations of 25-hydroxyvitamin D and different subtypes of age-related cataract; a case-control study

Naser Samadi Aidenloo 1* ORCID logo, Qader Motarjemizadeh 1* ORCID logo, Sanaz Moradi Nahriq 1

1 Department of Ophthalmology, Urmia University of Medical Sciences, Urmia, Iran
*Corresponding Authors: *Correspondence to Naser Samadi Aidenloo, Email: nasersamadiseye@ gmail.com, , Email: samadi.i@umsu. ac.ir; Qader Motarjemizadeh Emial: , Email: motarjemizadeh.q@umsu.ac.ir

Abstract

Introduction: Age-related cataract (ARC) is the principal causes of low vision and also the most prevalent type of cataract among the elderly population, particularly women.

Objectives: To evaluate the association between serum concentration of vitamin D and risk of different subtypes of senile cataract.

Patients and Methods: A total of 200 controls and 1241 patients with newly recognized ARC attending the ophthalmology ward of a major teaching hospital in Urmia, Iran, were included in this investigation. All included subjects aged 40 to 85 years. Cataracts were classified as pure nuclear cataract (NC) (n=216), pure cortical cataract (CC) (n=336), pure posterior sub-capsular cataract (PSC) (n=140) and mixed cataracts (549). Serum concentration of 25-hydroxyvitamin D was obtained from blood samples. All participants were administered by a questionnaires to collect data on demographic variables and risk factors.

Results: On multivariate analysis, a marked negative association (P < 0.05) was found between vitamin D serum levels and the risk of NC (OR = 0.20; 95% CI: 0.09-0.75) or CC (OR = 0.25; 95% CI: 0.12-0.96) in females only. Other significant predictors of pure NC in women were higher education (OR = 0.51) and serum calcium levels (OR = 0.35). Apart from serum concentrations of vitamin D, postmenopausal status (OR = 2.26) was the other predisposing factor for pure cortical opacity in women.

Conclusion: Our finding does not endorse a role for vitamin D in cataractogenesis among men. In women, however, serum levels of 25(OH)D were only inversely associated with the risk of NC and CC and not with PSC or mixed cataract. Providing sufficient vitamin D is possibly helpful in preventing senile cataract formation in females.



Citation: Samadi Aidenloo N, Motarjemizadeh Q, Moradi Nahriq S. Serum concentrations of 25-hydroxyvitamin D and different subtypes of age-related cataract; a case-control study. Immunopathol Persa. 2022;8(1):e16. DOI:10.34172/ ipp.2022.16.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 2480

Your browser does not support the canvas element.


PDF Download: 1374

Your browser does not support the canvas element.