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Submitted: 10 Oct 2020
Accepted: 03 Nov 2020
ePublished: 09 Nov 2020
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Immunopathol Persa. 2021;7(2): e23.
doi: 10.34172/ipp.2021.23
  Abstract View: 189
  PDF Download: 108

Original

Clinical course and outcome in diabetic patients with COVID-19

Zahra Davoudi 1 ORCID logo, Ilad Alavi Darazam 2 ORCID logo, Farnaz Saberian 3 ORCID logo, Sina Homaee 3 ORCID logo, Shervin Shokouhi 2 ORCID logo, Minoosh Shabani 2 ORCID logo, Latif Gachkar 2 * ORCID logo

1 Department of Endocrinology and Metabolism, Shahid Beheshti, University of Medical Sciences, Tehran, Iran
2 Infectious Diseases and Tropical Medicine Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3 Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
*Correspondence to Latif Gachkar, Email: gachkar@sbmu.ac.ir

Abstract

Introduction: As diabetes is highly prevalent worldwide, understanding particular dimensions of COVID-19 infection in diabetic patients is of significant importance.

Objectives: The present research aimed to evaluate the outcome of diabetic patients with COVID-19 infection, and the clinical and biochemical characteristics in survived and non-survived patients.

Patients and Methods: The present single-center, cross-sectional study examined laboratory and clinical features of 160 patients with diabetes who had moderate to severe criteria. The obtained data were categorized as survived or non-survived patients and then we compared the clinical characteristics in two groups.

Results: In this study, 160 diabetic patients (75 men and 85 women) admitted with moderate to severe Covid-19 were evaluated. The mean age of studied patients was 51-90 years old, with diabetes duration of 5 to 15 years. One hundred thirty-one patients (81.9%) survived, but twenty-nine patients (18.1%) did not survive. Regarding the comparison of symptoms, only the loss of consciousness on admission was higher in non- survived patients; however, a majority of the non-survivors have been admitted to ICU, 23(79.3%) and 26 (89.6%) needed invasive mechanical ventilation; in comparison to survived patients also had a shorter duration of hospital stay (5.5±5.1 versus 8.4±6.1days). Non–survivors more probably suffer from high blood pressure [23 (79.3%) patients versus 80 (61%) patients] and chronic kidney disease [20 (69%) patients versus 9 (6.9%) patients; P<0.001]. Glycated hemoglobin (HbA1c) of more than 9%, and high fasting blood sugar, severe inflammatory response, hepatic, renal, and coagulation impairment was higher in non–survived than those who survived.

Conclusion: Multifactorial parameters result in the poor prognosis in diabetic patients; therefore, it is critical for identifying the key clinical, as well as laboratory characteristics of COVID-19 cases that lead to severe disease and increase the risk of death.

Keywords: COVID-19 infection, Diabetes, Chronic kidney disease, Glycated hemoglobin
Citation: Davoudi Z, Alavi Darazam I, Saberian F, Homaee S, Shokouhi S, Shabani M, Gachkar L. Clinical course and outcome in diabetic patients with COVID-19. Immunopathol Persa. 2021;7(2):e23. DOI:10.34172/ ipp.2021.23.
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