Submitted: 09 Mar 2019
Accepted: 01 Apr 2019
ePublished: 07 Apr 2019
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Immunopathol Persa. 2019;5(1): e05.
doi: 10.15171/ipp.2019.05

Scopus ID: 85100875596
  Abstract View: 2215
  PDF Download: 1105

Original Article

The accuracy of selected hematology and inflammatory indices for predicting preterm labor; a cross-sectional study

Farah Farzaneh 1 ORCID logo, Shamin Ghobadi 1* ORCID logo, Abdorrahim Absalan 2 ORCID logo

1 Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Medical Laboratory Sciences, Khomein University of Medical Sciences, Markazi Province, Iran
*Corresponding Author: Email: Sh.ghobadi2006@gmail.com


Introduction: The role of inflammatory indices has been suggested in preterm labor.

Objectives: The possible relationship of some inflammatory and hematological markers were investigated as predictors of preterm labor.

Patients and Methods: Around 110 full-term and 109 preterm women were randomly enrolled. According to the gestational age at delivery, they were divided into two groups including <37 weeks and ≥37 weeks pregnancies. The patients’ age, body mass index (BMI), history of smoking were recorded. Selected hematological parameters, erythrocyte sedimentation rate (ESR) and high-sensitive C-reactive protein (hsCRP) were measured. Comparison of groups, the odd’s ratio and accuracy of each index were evaluated and assessed statistically.

Results: Overall, 110 full-term and 109 preterm mothers were evaluated. Mothers with preterm labor had higher WBC, hemoglobin, neutrophil proportion, neutrophil/lymphocyte ratio (NLR), platelet count, platelet/lymphocyte ratio (PLR), and ESR and also hs-CRP values. However, they had lower lymphocyte proportion than mothers with full-term delivery. Hs-CRP higher than 10.9 mg/L showed moderate sensitivity (50.46%) instead of high specificity (90.91%), while ESR >30 mm revealed 85.32% sensitivity and 93.64% specificity for predicting preterm labor. Lymphocyte ratio ≤22% and NLR >3.21 represented high sensitivity and plausible specificity. Hemoglobin >10.8 g/dL, platelet count >178000 cells/μL, PLR> 8.53 and WBC >7800 cells/μL showed adequate sensitivities with low to moderate specificities to predict preterm labor.

Conclusion: Most of the investigated variables were associated with preterm delivery. The cut-off values obtained here may help obstetricians to predict preterm delivery, and therefore to manage its complications, costs, hazards and care problems.

Citation: Farzaneh F, Ghobadi S, Absalan A. The accuracy of selected hematology and inflammatory indices for predicting preterm labor; a cross-sectional study. Immunopathol Persa. 2019;5(1):e05. DOI:10.15171/ ipp.2019.05.
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