Logo-ipp
Submitted: 13 Jan 2020
Accepted: 24 Mar 2020
ePublished: 06 May 2020
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Immunopathol Persa. 2020;6(2): e23.
doi: 10.34172/ipp.2020.23

Scopus ID: 85105080637
  Abstract View: 2256
  PDF Download: 1070

Original

Evaluation of the relationship between CD163 positive macrophages and prognostic factors in serous ovarian tumors

Mitra Heidarpour 1 ORCID logo, Marjan-Sadat Hoseini-Beheshti 1* ORCID logo, Maryam Derakhshan 1 ORCID logo

1 Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: *Correspondence to Marjan-Sadat HoseiniBeheshti, Email: , Email: marjanbeheshti89@ gmail.com

Abstract

Introduction: Ovarian cancer is the seventh most common cancer in women and is the fifth most common cause of mortality from malignancy.

Objectives: The present study was performed to evaluate the number of CD163 positive macrophages and prognostic factors in serous ovarian tumors.

Materials and Methods: In the present cross-sectional study, 43 tissue samples obtained from patients with serous ovarian tumors were selected from the pathology ward of Al-Zahra hospital, Isfahan, Iran. Then, the patients’ demographic information including age, pathological results, clinical stage of the disease, degree of tissue differentiation, the number of CD163 positive macrophages, and the five-year survival rate after the surgery were recorded and evaluated.

Results: Patient age, International Federation of Gynecology and Obstetrics (FIGO) stage, histological grade, lymphatic metastasis, and the five-year survival rate were positively and significantly associated with the number of CD163 positive macrophages (P <0.05). In addition, the number of CD163 positive macrophages increased the odds of the five-year survival rate in these patients by 1.490 times (P = 0.026).

Conclusion: According to the results of this study, the number of CD163 positive macrophages had a significant association with the progression of ovarian cancer. Moreover, the increased number of CD163 positive macrophages increased the chance of mortality in these patients.


Citation: Heidarpour M, Hoseini-Beheshti MS, Derakhshan M. Evaluation of the relationship between CD163 positive macrophages and prognostic factors in serous ovarian tumors. Immunopathol Persa. 2020;6(2):e23. DOI:10.34172/ ipp.2020.23.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 2257

Your browser does not support the canvas element.


PDF Download: 1070

Your browser does not support the canvas element.