Abstract
Introduction: Post-pericardiotomy syndrome is a relatively common complication after open heart surgery. In recent
years, colchicine had a good effect on treatment of the pericarditis.
Objectives: This study aimed to study the effect of colchicine to prevent post-pericardiotomy syndrome in patients
who had open heart surgery.
Patients and Methods: This double-blind clinical trial study was conducted on 240 patients undergone open heart
surgery. Eligible patients were selected by simple sampling and randomly divided into two groups; 120 subjects in
the experimental group receive colchicine (1 mg for patients greater than 70 kg and 0.5 mg for patients lower than
70 kg) and 120 subjects in the control group who received the placebo. Patients were followed up regarding the
incidence of post-pericardiotomy syndrome after the surgery during hospitalization and in follow up visits in one
month and six months after hospital discharges.
Results: In total, the incidence rate of post-pericardiotomy syndrome was 33.7% (81 subjects). A significant difference
of post-pericardiotomy syndrome between two groups was seen. We found post-pericardiotomy syndrome in 12.1%
(29 patients) of colchicine group versus 21.6% (52 patients) in the placebo group (chi-square test). The incidence rate
based on the Kaplan-Meier curve, in the second week to one month after the surgery, was lower in colchicine group
while in third to the sixth month it had a constant trend.
Conclusion: Colchicine is effective for prevention the post-pericardiotomy syndrome without any life-threatening
complication.