Oral Candida colonization in renal disease patients between diabetes and non-diabetes; a comparative study

Bhargavi Krishna Ayinampudi, Aparna Rao Chervu, Sree Bhushan Raju, Venkat Baghirath Pacha


Introduction:  Oral  colonization  with  fungi  requires  attainment  from  the  oral  atmosphere, attachment and growth replication but host defense acts to remove or kill invading fungi. This function is hampered in renal failure patients. This is the reason why in case of immune system
defects, a rise in Candida colonization is seen. Oral candidiasis is a common opportunistic infection in immune-suppressed and immune-compromised patients.
Objectives: This study is planned to see the existence of Candida in different renal conditions with diabetic and non-diabetic etiology.
Patients and Methods: The study comprises a total of 45 patients, which includes 15 chronic kidney disease (CKD) patients, 15 end-stage renal disease (ESRD) and 15 renal transplanted patients. Each group is further divided as diabetic (group 1) and non-diabetic (group 2). Whole
saliva samples were cultured on Candida chrome agar.
Results: Each group showed positivity for Candida species with the highest positivity of a total of 67% in CKD group. The diabetic group (group 1) showed 64% positivity and non-diabetic group (group 2) showed 55% positivity respectively.
Conclusion:  Immunosuppression  states  like  CKD,  ESRD  and  renal  transplant  recipients  are associated with increased risk of oral Candida colonization and diabetic further worsens this


Key point
This  study  showed  the  prevalence  of Candida  in  3  groups.  As  the  prevalence is  more  in  transplant  group,  clinicians should  have  a  low  threshold  to  diagnose in  transplant  patient  that  ultimately  leads
to  early  initiation  of  treatment  and  thus morbidity  and  mortality  can  be  improved in  long  run.


Citation: Ayinampudi BK, Chervu AR, Raju SB, Pacha VB. Oral Candida colonization in renal disease patients between diabetes and non-diabetes; a comparative study. Immunopathol Persa. 2018;4(1):e08. DOI:

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