The role of microRNAs in human cancers

Mohammad-Reza Mahmoudian-Sani, Ameneh Mehri-Ghahfarrokhi, Ali Shojaeian, Majid Asadi-Samani, Tahra Luther

Abstract


MicroRNAs consist of 18 to 25 non-coding ribonucleic acids (RNA) that can act as oncogenes or tumor suppressors and in which mutations can lead to cancer. The identification of microRNAs and their target molecules has created a new horizon for studies of causes of cancer. MicroRNAs can be used as potential biological markers in diagnosis, prediction and treatment of cancers. This review article presents findings to explain microRNA’s function in human cancers.

 

Key point
MicroRNAs can act as oncogenes or tumor suppressors.  Mutations  in  microRNAs  can lead  to  cancer.  Detection  of  changes  in microRNA  expression  can  be  used  for prediction,  prevention,  and  treatment  of
cancers.

 

Citation: Mahmoudian-Sani MR, Mehri-Ghahfarrokhi A, Shojaeian A, Asadi-
Samani M, Luther T.  The role of microRNAs in human cancers. Immunopathol Persa. 2018;4(1):e05. DOI:10.15171/ipp.2018.05.


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