An overview on natural antioxidants for oxidative stress reduction in cancers; a systematic review

Neda Gholamian-Dehkordi, Tahra Luther, Majid Asadi-Samani, Mohammad Reza Mahmoudian-Sani


Tumor cells have deviated pathway that lead to increased constant state levels of free radicals and consequently lead to DNA damage, and then activates signaling pathways that causes unlimited growth, the inability to differentiation, and the malignant phenotype. Some studies have demonstrated that antioxidants can inhibit free radicals generation and repress oxidative damage and can prevent the creation of most diseases like cancer. There are some studies that investigated the mechanism and regulative effects of herbal extract antioxidant carcinogenesis prevention; they have documented that antioxidant effects and the inhibition of cancer development depends on a number of basic cellular mechanisms by phenolic compounds including a spectrum of cellular basic machinery. This systematic review aimed at providing an overview on the relevant data available in antioxidant activity of herbal products for cancer prevention and treatment. In this regards, Web of Science and PubMed databases were searched by the application of Endnote software for the publications about the role of herbal antioxidants on cancer; published from 2000 to February 2016. This study can/might provide a new horizon on the design of anticancer herbal medicines.


Key point
Natural antioxidant agents have role in reducing agents, hydrogen donors, quenchers of singlet oxygen, delay oxidative reactions, and significantly terminate oxidative chain reactions by removing the free radical intermediates. Natural antioxidant can promote the arrest of cell cycle and death of cancer cells.


Citation: Gholamian-Dehkordi N, Luther T, Asadi-Samani M, Mahmoudian-Sani MR. An overview on natural antioxidants for oxidative stress reduction in cancers; a systematic review. Immunopathol Persa. 2017;3(2):e12.

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