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Submitted: 15 Aug 2019
Accepted: 02 Nov 2019
ePublished: 16 Dec 2019
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Immunopathol Persa. 2020;6(1): e04.
doi: 10.15171/ipp.2020.04
  Abstract View: 298
  PDF Download: 197

Original

Predictive value of platelet indices in children with idiopathic nephrotic syndrome

Azar Nickavar 1 ORCID logo, Sahar Sadr Moharerpour 2 * ORCID logo, Ehsan Abiry 3 ORCID logo

1 Pediatric Nephrology Department, Iran University of Medical Sciences, Tehran, Iran
2 Non-communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3 Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
*Correspondence to Sahar Sadr Moharerpour, Email: s.sadr@mubabol.ac.ir

Abstract

Introduction: Different biomarkers have been investigated for prognosis of patients with nephrotic syndrome. Qualitative and quantitative changes have been reported in platelets in these patients.

Objectives: The aim of this study was to identify platelet abnormalities and their prognostic value of steroid response in children with idiopathic nephrotic syndrome.

Patients and Methods: Platelet counts and indices (mean platelet volume [MPV], platelet distribution width [PDW] and platelet larger cell ratio [PLCR]) were evaluated and compared in 122 children with active nephrotic syndrome (64%; steroid resistant and 36%; steroid sensitive).

Results: Mean age at diagnosis was 55 months (6 to169 months), and males outnumbered females (1.7/1). Steroid resistant patients had significantly higher platelet counts and lower PLCR, compared to steroid sensitive group. Regarding area under the ROC curve, low MPV, high PDW and low PLCR showed relatively acceptable correlation with steroid resistance.

Conclusion: Increased platelet counts in addition to low PLCR are the suggestive indicators of steroid resistance in children with idiopathic nephrotic syndrome.

Keywords: Nephrotic syndrome, Platelets, Prognosis, Steroid response, Mean platelet volume, Children
Citation: Nickavar A, Sadr Moharerpour S, Abiry E. Predictive value of platelet indices in children with idiopathic nephrotic syndrome. Immunopathol Persa. 2020;6(1):e04. DOI:10.15171/ ipp.2020.04.
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