Abstract
Introduction: Different biomarkers have been investigated for prognosis of patients with nephrotic syndrome.
Qualitative and quantitative changes have been reported in platelets in these patients.
Objectives: The aim of this study was to identify platelet abnormalities and their prognostic value of steroid
response in children with idiopathic nephrotic syndrome.
Patients and Methods: Platelet counts and indices (mean platelet volume [MPV], platelet distribution width
[PDW] and platelet larger cell ratio [PLCR]) were evaluated and compared in 122 children with active nephrotic
syndrome (64%; steroid resistant and 36%; steroid sensitive).
Results: Mean age at diagnosis was 55 months (6 to169 months), and males outnumbered females (1.7/1).
Steroid resistant patients had significantly higher platelet counts and lower PLCR, compared to steroid sensitive
group. Regarding area under the ROC curve, low MPV, high PDW and low PLCR showed relatively acceptable
correlation with steroid resistance.
Conclusion: Increased platelet counts in addition to low PLCR are the suggestive indicators of steroid resistance
in children with idiopathic nephrotic syndrome.