Logo-ipp
Submitted: 18 Sep 2019
Accepted: 15 Nov 2019
ePublished: 14 Dec 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Immunopathol Persa. 2020;6(1): e03.
doi: 10.15171/ipp.2020.03
  Abstract View: 111
  PDF Download: 111

Original

Association of FOXP3 gene polymorphisms with risk of preeclampsia in Lur population of Iran

Soheila Akbari 1 ORCID logo, Farhad Shahsavar 2 ORCID logo, Babak Khodadadi 3 ORCID logo, Seyyed Amir Yasin Ahmadi 4 ORCID logo, Saber Abbaszadeh 3,5 ORCID logo, Seyyed Ezatollah Rafiei Alavi 6 * ORCID logo

1 Department of Obstetrics and Gynecology, Lorestan University of Medical Sciences, Khorramabad, Iran
2 Department of Immunology, Lorestan University of Medical Sciences, Khorramabad, Iran
3 Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran
4 Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran
5 Scientific Society of Evidence-based Knowledge, Research Office for the History of Persian Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
6 Department of Pathology, Lorestan University of Medical Sciences, Khorramabad, Iran
*Correspondence to Seyyed Ezatollah Rafiei Alavi, Email: erafieialavi@gmail. com, ezatollah.rafieialavi@ lums.ac.ir

Abstract

Introduction: Regulatory T lymphocytes have an effective role in induction of immune tolerance and angiogenesis during pregnancy. Differentiation and replication of these lymphocytes from other T cells is controlled by FOXP3 transcriptional factor. FOXP3 gene is polymorphic.

Objectives: This study was designed to investigate the role FOXP3 common polymorphisms in susceptibility to preeclampsia in Lur populations of Lorestan province of Iran.

Patients and Methods: This study was conducted on three polymorphisms rs2232365 A/G, rs3761548 C/A and rs5902434 del/ATT using polymerase chain reaction with sequence specific primers (PCR SSP). A total of 100 participants were subjected to be studied. Data analysis was done using Fisher’s exact test and multivariate logistic regression.

Results: In rs2232365 polymorphism, AA genotype was a risk factor (P=0.002) and AG genotype was a protecting factor (P<0.001). In polymorphism of rs3761548, CA genotype was a risk factor (P=0.036) and AA genotype was a protecting factor (P=0.015). In polymorphism rs5902434, del/del genotype was a risk factor (P=0.013) and del/ATT genotype was a protecting factor (P<0.001). After adjusting the effects of genotypes, CA genotype of rs3761584 polymorphism was considered as an attributable risk factor (P=0.040; odds ratio [OR] =4.19).

Conclusion: The present population showed a unique association for the role of FOXP3 polymorphism in susceptibility to preeclampsia in comparison to previous studies.

Keywords: Preeclampsia, Regulatory T lymphocytes, FOXP3
Citation: Akbari S, Shahsavar F, Khodadadi B, Ahmadi SAY, Abbaszadeh S, Rafiei Alavi SE. Association of FOXP3 gene polymorphisms with risk of preeclampsia in Lur population of Iran. Immunopathol Persa. 2020;6(1):e03. DOI:10.15171/ ipp.2020.03. 
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 111

Your browser does not support the canvas element.


PDF Download: 111

Your browser does not support the canvas element.