Submitted: 26 Sep 2019
Accepted: 09 Dec 2019
ePublished: 24 Dec 2019
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Immunopathol Persa. 2020;6(1): e06.
doi: 10.15171/ipp.2020.06
  Abstract View: 590
  PDF Download: 274

Original Article

Is FEV1 associated with quality of life in children with cystic fibrosis? An original article

Rohola Shirzadi 1 ORCID logo, Safoura Navaei 1 ORCID logo, Mohammadreza Modaresi 1 ORCID logo, Farzad Masiha 2 ORCID logo

1 Pediatric Respiratory and Sleep Medicine Research Center, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
2 Pediatric Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran


Introduction: Cystic fibrosis (CF) is a serious genetic life-shortening disease. Quality of life (QoL) measurement related to CF children is a relatively new field of research, which includes the patient’s perspective in research and clinical practice.

Objectives: This study aimed to evaluate the QoL in children with CF and its association with FEV1 (forced expiratory volume in 1 second).

Patients and Methods: This cross-sectional study was carried out on 7-14 years old children with CF attending children’s medical center from March 2017 to March 2018. Throat swab cultures and spirometry evaluation was performed for all patients. FEV1 was determined and the 6-min walk test (6MWT) was conducted. The patient’s psychological status was assessed using the Persian version of pediatric QoL inventory. ANOVA, t test, and chisquare tests were used for data analysis.

Results: Seventy-six subjects with the mean age of 10.49±3.18 years were studied since 59% of them (n=44) were boys. The mean total QoL was 65.34±17.73. Patients with lower pulmonary function had a lower QoL. There was a significant association between FEV1 and school and emotional functioning (P=0.005 and P=0.002, respectively). A significant association was found between SPO2 (peripheral capillary oxygen saturation) reduction after 6MWT and FEV1 decline (P=0.001). Additionally, a significant association was detected between FEV1 and the distance walked during 6MWT (P=0.030).

Conclusion: Regarding the association between pulmonary function and QoL in CF patients and lower QoL score in our study, the importance of assessing pulmonary function in these patients should not be neglected.  

Keywords: Pulmonary function, Cystic fibrosis, Spirometry, Quality of life
Citation: Shirzadi R, Navaei S, Modaresi M, Masiha F. Is FEV1 associated with quality of life in children with cystic fibrosis? An original article. Immunopathol Persa. 2020;6(1):e06. DOI:10.15171/ ipp.2020.06.
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