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Submitted: 18 Oct 2016
Accepted: 14 Dec 2016
ePublished: 29 Dec 2016
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Immunopathol Persa. 2017;3(2): e11.
doi: 10.15171/ipp.2017.03
  Abstract View: 1279
  PDF Download: 733

Review

Oxidative stress, free radicals, kidney disease and plant antioxidants

Fatemeh Dehghan Shahreza 1 *

1 Department of Clinical Science, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran
Correspondence to Fatemeh Dehghan Shahreza F_dehghan66@yahoo.com

Abstract

Over generation of reactive molecules leads to oxidative stress which is a causative agent of many diseases occurrence including kidney disease. Oxidative stress at kidney tissue induces the cellular signaling pathways which may activate construction of growth and pro-inflammatory mediators, finally, lead to glomerulosclerosis and renal fibrosis. Both enzymatic and low molecular weight antioxidants are able to ameliorate these injurious impacts. Therefore, antioxidants are chemoprotective agents that neutralize cellular macromolecules oxidative damages. Numerous components are recognized to exert antioxidative properties that are originated from medicinal plants and have been administering as resourceful therapeutic approach in various diseases such as kidney failure. Therefore, we summarized the nephron-protective effects of several medicinal plants which are recently investigated at clinical trials. 
Keywords: Oxidative stress, Endothelial dysfunction, Endothelial dysfunction, Renal injury, Diabetes mellitus, Reactive oxygen species
Citation: Dehghan Shahreza F. Oxidative stress, free radicals, kidney disease and plant antioxidants. Immunopathol Persa. 2017;3(2):e11. DOI: 10.15171/ipp.2017.03.
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