Submitted: 07 Mar 2020
Accepted: 03 May 2020
ePublished: 27 May 2020
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Immunopathol Persa. 2021;7(1): e02.
doi: 10.34172/ipp.2021.02
  Abstract View: 577
  PDF Download: 408

Original Article

Astragalus fasciculifolius manna; antinociceptive, antiinflammatoryand antioxidant properties in mice

Mehrdad Shahrani 1 * , Najmeh Asgharzadeh 1, Akram Torki 1, Shirin Asgharian 1, Zahra Lorigooini 1

1 Medicinal Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran


Introduction: Inflammation is one of the body›s natural defence mechanisms alongside the cells or tissues damage due to various stimuli or infections. Pain is one of the greatest common symbols associated with different diseases. Therefore, researchers are trying to find new medications that bring patients relief with fewer side effects. Herbal medicine has been used for periods to treat acute and chronic pains.

Objectives: This research evaluated the anti-inflammatory, antinociceptive and antioxidant properties of Astragalus fasciculifolius manna extract. Materials and Methods: The anti-inflammatory and antioxidant potency of the extract were determined by xylene test and ferric reducing antioxidant power assay.

Results: Astragalus fasciculifolius manna extract at doses of 400, 800 and 1200 mg/kg significantly reduced acetic acid-induced writhing and formalin-induced paw licking (late and early phase) but did not affect mechanical hyperalgesia caused by heat. Moreover, naloxone failed to inhibit the antinociceptive activity of the extract. The extract of A. fasciculifolius manna also exhibited high anti-inflammatory activity against xylene induced ear edema. Treatment of mice with the extract did not improve serum antioxidant capacity.

Conclusion: Results of the present research showed that A. fasciculifolius manna can prevent pain and inflammation because of the presence of high amount of saponin.

Keywords: Astragalus fasciculifolius manna, Antiinflammatory, Antinociceptive, Antioxidant activity
Citation: Shahrani M, Asgharzadeh N, Torki A, Asgharian S, Lorigooini Z. Astragalus fasciculifolius manna; antinociceptive, antiinflammatory and antioxidant properties in mice. Immunopathol Persa. 2021;7(1):e02. DOI:10.34172/ ipp.2021.02.
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