Logo-ipp
Submitted: 02 May 2020
Accepted: 13 May 2020
ePublished: 19 May 2020
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)

Immunopathol Persa. 2020;6(2): e27.
doi: 10.34172/ipp.2020.27
  Abstract View: 310
  PDF Download: 205

Mini-Review

The footprint of androgen sensitive serine protease (TMPRSS2) in gender mortality with COVID-19

Sepideh Zununi Vahed 1 ORCID logo, Shahram Ghiyasvand 1 ORCID logo, Ramin Tolouian 2 ORCID logo, Hamid Noshad 1 ORCID logo, Audrey Tolouian 3 ORCID logo, Mohammadali Mohajel Shoja 4 ORCID logo, Mohammadreza Ardalan 1 * ORCID logo

1 Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Division of Nephrology, College of Medicine, University of Arizona, Tucson, AZ, USA
3 School of Nursing, The University of Texas at El Paso, TX, USA
4 Department of Surgery, University of Illinois at Chicago-Metropolitan Group Hospitals (UIC-MGH), Chicago, Illinois, USA
*Correspondence to Prof. Mohammadreza Ardalan, Email: ardalan34@yahoo.com

Abstract

Male gender is an obvious risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mortality rate is higher in men than women. Undoubtedly, gender-related behavioral factors, such as higher amounts of smoking, alcohol consumption, and biological differences in immune systems could make males more vulnerable. The role of androgen-responsive elements (AREs) of transmembrane serine proteases type II (TMPRSS2) gene as one of the major players of male dominancy in severe COVID-19 infection has been under appreciated and needs to be clarified.
Keywords: SARS-Cov-2, TMPRSS2, nCov-19, Androgen, Gender mortality, COVID-19, Serine protease
Citation: Zununi Vahed S, Ghiyasvand S, Tolouian R, Noshad H, Tolouian A, Mohajel Shoja M, Ardalan M. The footprint of androgen sensitive serine protease (TMPRSS2) in gender mortality with COVID-19. Immunopathol Persa. 2020;6(2):e27. DOI:10.34172/ipp.2020.27.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 310

Your browser does not support the canvas element.


PDF Download: 205

Your browser does not support the canvas element.