Submitted: 02 May 2020
Accepted: 13 May 2020
ePublished: 19 May 2020
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Immunopathol Persa. 2020;6(2): e27.
doi: 10.34172/ipp.2020.27
  Abstract View: 310
  PDF Download: 205


The footprint of androgen sensitive serine protease (TMPRSS2) in gender mortality with COVID-19

Sepideh Zununi Vahed 1 ORCID logo, Shahram Ghiyasvand 1 ORCID logo, Ramin Tolouian 2 ORCID logo, Hamid Noshad 1 ORCID logo, Audrey Tolouian 3 ORCID logo, Mohammadali Mohajel Shoja 4 ORCID logo, Mohammadreza Ardalan 1 * ORCID logo

1 Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Division of Nephrology, College of Medicine, University of Arizona, Tucson, AZ, USA
3 School of Nursing, The University of Texas at El Paso, TX, USA
4 Department of Surgery, University of Illinois at Chicago-Metropolitan Group Hospitals (UIC-MGH), Chicago, Illinois, USA
*Correspondence to Prof. Mohammadreza Ardalan, Email: ardalan34@yahoo.com


Male gender is an obvious risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and mortality rate is higher in men than women. Undoubtedly, gender-related behavioral factors, such as higher amounts of smoking, alcohol consumption, and biological differences in immune systems could make males more vulnerable. The role of androgen-responsive elements (AREs) of transmembrane serine proteases type II (TMPRSS2) gene as one of the major players of male dominancy in severe COVID-19 infection has been under appreciated and needs to be clarified.
Keywords: SARS-Cov-2, TMPRSS2, nCov-19, Androgen, Gender mortality, COVID-19, Serine protease
Citation: Zununi Vahed S, Ghiyasvand S, Tolouian R, Noshad H, Tolouian A, Mohajel Shoja M, Ardalan M. The footprint of androgen sensitive serine protease (TMPRSS2) in gender mortality with COVID-19. Immunopathol Persa. 2020;6(2):e27. DOI:10.34172/ipp.2020.27.
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