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Submitted: 09 Feb 2020
Accepted: 10 Apr 2020
ePublished: 23 May 2020
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Immunopathol Persa. 2020;6(2): e26.
doi: 10.34172/ipp.2020.26
  Abstract View: 221
  PDF Download: 110

Original

Effective factors on clinical outcomes of children with osteosarcoma and Ewing bone tumors

Sasan Hejazi 1 ORCID logo, Mehran Noroozi 1 * ORCID logo, Mohammad Amin Kuhestani 2, Farid Ghazizadeh 1 ORCID logo, Mohammad Karmiyar 3, Ebrahim Sadeghi 3 ORCID logo, Ahad Ghazavi 4 ORCID logo, Hamidreza Houshmand 5 ORCID logo

1 Department of Pediatric Hematology and Oncology, Motahari Hospital, Urmia University of Medical Sciences, Urmia, Iran
2 Urmia University of Medical Sciences, Urmia, Iran
3 Department of Pediatric Infectious Disease, Motahari Hospital, Urmia University of Medical Sciences Urmia, Iran
4 Associate Professor of Pediatric Neurology, Neurophysiology Research Center, Urmia University of Medical Sciences, Urmia, Iran
5 Department of Pediatric Immunology and Allergy, Motahari Hospital, Urmia University of Medical Sciences, Urmia, Iran
*Correspondence to Mehran Noroozi, Email: mehranxnoroozi@ gmail.com

Abstract

Introduction: Malignant bone tumors account for 6% of childhood malignancies. The peak incidence rate for bone cancer is in adolescents. Geographic and race differences in incidence rate of bone tumors are important for correct diagnosis and treatment.

Objectives: This study aimed to investigate the demographic features of patients with malignant bone tumors and prognostic factors.

Patients and Methods: In a retrospective study, records of all patients diagnosed and treated for malignant bone tumor from March 1996 to February 2014 were investigated. Data were collected using checklists and analyzed using SPSS software.

Results: The most common type of bone tumor was Ewing sarcoma (73.7%) in patients who were over 10 years old (87.5%). Primary site of disease in most cases of osteosarcoma and Ewing sarcoma was distal femur (50% and 27.3%, respectively). Most common clinical manifestation was local pain and mass (88.5%). Regarding metastasis, 72.7% of osteosarcoma patients and 32.4% of Ewing sarcoma patients had metastasis. There was not statistically relationship between survival rate and gender, age group and stage of disease at diagnosis time. One, three and five-year survival rate was lower than the previous studies.

Conclusion: The incidence of Ewing sarcoma is more then osteosarcoma in West Azerbaijan. In our study there were no statistically important differences in survival rates of patients with metastasis at diagnosis time and those without metastasis.

Keywords: Malignant bone tumors, Ewing sarcoma, Osteosarcoma, Survival, Metastasis
Citation: Hejazi S, Noroozi M, Kuhestani MA, Ghazizadeh F, Karmiyar M, Sadeghi E, et al. Effective factors on clinical outcomes of children with osteosarcoma and Ewing bone tumors. Immunopathol Persa. 2020;6(2):e26. DOI:10.34172/ ipp.2020.26.
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